ArticleResearch square2024
Diffusion Tensor Imaging of Rat Rotator Cuff Muscle with Histopathological Correlation: An Exploratory Study.
Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that can be used to assess microstructural features of skeletal muscle that are related to tissue function. Although widely used, direct correlations between DTI derived metrics such as fractional anisotropy and spatially matched tissue microstructure assessed with histology have not been performed. This study investigated the relationship between scalar-based DTI measurements and histologically derived muscle microstructural measurements in rat rotator cuff muscles. Despite meticulous co-localization of MRI and histology data, negligible correlations were found between DTI metrics and histological measurements including muscle fiber diameter, cross-sectional area, and surface-to-volume ratio. These findings highlight the challenges in validating DTI with histology due to requirements in anatomical co-localization, necessity of high-quality histology, and consideration of diffusion measurement scales. Our findings underscore the need for further research with optimized imaging parameters to enhance our knowledge regarding the sensitivity of DTI to important features of muscle microstructure.
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