Evidence map›Paper›PMID 39281867›Full record

ArticleResearch square2024

The signaling cascade of induction and maintenance of ES cell diapause.

Alexander Tarakhovsky, Tuo Zhang, Ryan Marina, Sarah Veugelen, Pal Mander, Rabinder Prinjha, Anne Schaefer, Karen Adelman

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander TarakhovskyLaboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University.
Tuo ZhangThe Rockefeller University.
Ryan MarinaHarvard Medical School.ORCID 0000-0003-2427-7912
Sarah VeugelenMax Planck Institute for Biology of Ageing.
Pal ManderGlaxoSmithKline.
Rabinder PrinjhaGlaxo SmithKline.ORCID 0000-0002-2666-3326
Anne Schaefer
Karen AdelmanHarvard Medical School.ORCID 0000-0001-5364-334X

Funding

Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YASMIN L. HURD · 2019 to 2026
$16.5M
Neuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's diseaseR01AG072489 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALISON M GOATE, Anne Schaefer · 2022 to 2026
$6.3M
Age-dependent activation of microglia inflammatory state and its epigenetic modulationRF1AG068558 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2020 to 2020
$3.0M
Transcriptional Control of Microglia Diversification and InflammationR01NS106721 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2020 to 2024
$2.0M
Age-dependent activation of microglia inflammatory state and its epigenetic modulationR01AG068558 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2024 to 2024
$726k
NIA NIH HHS R01 AG072489NIA NIH HHS RF1 AG068558NIDA NIH HHS P01 DA047233NINDS NIH HHS R01 NS106721
6 · The paper itself

Abstract

Nutrient deficiency during pregnancy in numerous animal species can induce the state of embryonic diapause. Diapause is characterized by changes in protein and gene expression that minimize the organism's reliance on external energy sources and ensure survival. Remarkably, the systematic changes associated with diapause appear to spare the gene expression program that supports embryonic cells' maintenance in the pluripotent state. The phenomenon of the differentiation "freeze" during diapause can be reproduced

Identifiers

PMID39281867
PMCPMC11398561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.