Evidence map›Paper›PMID 39282340›Full record

ArticlebioRxiv : the preprint server for biology2024

Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations.

Harinder Singh, Rosana Wiscovitch-Russo, Claire Kuelbs, Josh Espinoza, Amanda E Appel, Ruth J Lyons, Sanjay Vashee, Hagen E A Förtsch, Jerome E Foster, Dan Ramdath and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Harinder SinghInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.
Rosana Wiscovitch-RussoInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.
Claire KuelbsGenomic Medicine Group, J. Craig Venter Institute, Rockville, MD, USA.
Josh EspinozaGenomic Medicine Group, J. Craig Venter Institute, Rockville, MD, USA.
Amanda E AppelInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.
Ruth J LyonsGarvan Institute of Medical Research, New South Wales, Australia.
Sanjay VasheeInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.
Hagen E A FörtschWindhoek Central Hospital, Windhoek Khomas, Namibia.
Jerome E FosterFaculty of Medical Sciences, University of the West Indies, Trinidad.
Dan RamdathFaculty of Medical Sciences, University of the West Indies, Trinidad.
Vanessa M HayesGarvan Institute of Medical Research, New South Wales, Australia.
Karen E NelsonInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.
Norberto Gonzalez-JuarbeInfectious Diseases Group, J. Craig Venter Institute, Rockville, MD, USA.

Funding

Dietary modulation of gut microbiome and host gene expression across human evolution and the emergence of modern human diseaseR01DK112381 · NIDDK · J. CRAIG VENTER INSTITUTE, INC. · PI SINGH, HARINDER · 2017 to 2020
$1.7M
NIDDK NIH HHS R01 DK112381
6 · The paper itself

Abstract

Societies with exposure to preindustrial diets exhibit improved markers of health. Our study used a comprehensive multi-omic approach to reveal that the gut microbiome of the Ju/'hoansi hunter-gatherers, one of the most remote KhoeSan groups, exhibit a higher diversity and richness, with an abundance of microbial species lost in the western population. The Ju/'hoansi microbiome showed enhanced global transcription and enrichment of complex carbohydrate metabolic and energy generation pathways. The Ju/'hoansi also show high abundance of short-chain fatty acids that are associated with health and optimal immune function. In contrast, these pathways and their respective species were found in low abundance or completely absent in Western populations. Amino acid and fatty acid metabolism pathways were observed prevalent in the Western population, associated with biomarkers of chronic inflammation. Our study provides the first in-depth multi-omic characterization of the Ju/'hoansi microbiome, revealing uncharacterized species and functional pathways that are associated with health.

Indexed as

Afro-TrinidadianagropastoralBantuCaribbeandiabeticsdietary patternsGut microbiomehealthyhunter-gatherersJu/’hoansimetabolomicsmetagenomicsmetatranscriptomicsmulti-omicsobese

Identifiers

PMID39282340
PMCPMC11398329

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.