Evidence map›Paper›PMID 39282425›Full record

ArticlebioRxiv : the preprint server for biology2025

Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.

Jennifer M Umhoefer, Maya M Arce, Sean Whalen, Rama Dajani, Laine Goudy, Sivakanthan Kasinathan, Julia A Belk, Wenxi Zhang, Royce Zhou, Sanjana Subramanya and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jennifer M UmhoeferGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0002-8563-9641
Maya M ArceGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Sean WhalenGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Rama DajaniGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Laine GoudyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Sivakanthan KasinathanGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Julia A BelkCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Wenxi ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Royce ZhouGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Sanjana SubramanyaGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Rosmely HernandezGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Carinna TranGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Nikhita KirthivasanGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Jacob W FreimerGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Cody T MoweryGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Vinh NguyenGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Mineto OtaGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Benjamin G GowenInnovative Genomics Institute, University of California, Berkeley, CA, USA.
Dimitre R SimeonovDepartment of Medicine, University of California, San Francisco, CA, USA.
Gemma L CurieInnovative Genomics Institute, University of California, Berkeley, CA, USA.
Zhongmei LiGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Jacob E CornDepartment of Biology, Institute of Molecular Health Sciences, ETH Zürich, Switzerland.ORCID 0000-0002-7798-5309
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Luke A GilbertArc Institute, Palo Alto, CA, USA.
Ansuman T SatpathyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Katherine S PollardGladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Alexander MarsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Integration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3M
Training Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
BD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544k
Functional mapping of ex-regulatory T cell phenotypic diversityF30AI157167 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOWERY, CODY · 2021 to 2023
$130k
NCRR NIH HHS S10 RR028962NHGRI NIH HHS R01 HG008140NIAID NIH HHS F30 AI157167NIAID NIH HHS T32 AI007334NIAMS NIH HHS T32 AR050942NIDDK NIH HHS T32 DK007418NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T cells (Tconvs). Mechanisms governing these distinct expression patterns remain unknown. Here, we performed CRISPR screens tiling the

Identifiers

PMID39282425
PMCPMC11398386

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.