Evidence map›Paper›PMID 39282448›Full record

ArticlebioRxiv : the preprint server for biology2025

A flexible photoacoustic retinal prosthesis.

Audrey Leong, Yueming Li, Thijs R Ruikes, Julien Voillot, Yuhao Yuan, Guo Chen, Clémence Bradic, Arnaud Facon, Chakrya-Anna Chhuon, Corentin Joffrois and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Audrey LeongSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.ORCID 0009-0009-8340-5524
Yueming LiDepartment of Electrical and Computer Engineering, Boston University, Boston, MA, 02215, United States.ORCID 0000-0002-0618-0722
Thijs R RuikesSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.ORCID 0000-0002-9886-0011
Julien VoillotAxorus SAS, Loos, 59120, France.
Yuhao YuanDepartment of Electrical and Computer Engineering, Boston University, Boston, MA, 02215, United States.ORCID 0000-0003-0731-0127
Guo ChenDepartment of Electrical and Computer Engineering, Boston University, Boston, MA, 02215, United States.ORCID 0000-0003-0239-0068
Clémence BradicSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.
Arnaud FaconAxorus SAS, Loos, 59120, France.
Chakrya-Anna ChhuonAxorus SAS, Loos, 59120, France.ORCID 0000-0001-7210-3699
Corentin JoffroisSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.
Gilles TessierSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.ORCID 0000-0003-3558-925X
Marion CorneboisSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.
Julie DégardinSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.ORCID 0000-0001-6515-8421
Jean-Damien LouiseAxorus SAS, Loos, 59120, France.
Ji-Xin ChengDepartment of Electrical and Computer Engineering and Department of Biomedical Engineering, Boston University, Boston, MA, 02215, United States.ORCID 0000-0002-5607-6683
Chen YangDepartment of Electrical and Computer Engineering and Department of Chemistry, Boston University, Boston, MA, 02215, United States.ORCID 0000-0001-9454-847X
Hélène MouletAxorus SAS, Loos, 59120, France.
Serge PicaudSorbonne Université, CNRS, INSERM, Institut de la Vision, F-75012 Paris, France.ORCID 0000-0002-0548-5145

Funding

Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recordingR01NS109794 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN, HAN, XUE · 2018 to 2022
$3.6M
Massively Parallel Optoacoustic Retinal Stimulation at Micrometer-ResolutionR21EY035437 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI YANG, CHEN · 2023 to 2025
$680k
Injectable Optoacoustic Retina ProsthesesR21EY036579 · NEI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI YANG, CHEN · 2024 to 2024
$589k
NEI NIH HHS R21 EY035437NEI NIH HHS R21 EY036579NINDS NIH HHS R01 NS109794
6 · The paper itself

Abstract

Retinal degenerative diseases of photoreceptors are a leading cause of blindness with no effective treatment. Retinal prostheses aim to restore sight by stimulating residual retinal cells. Here, we present a photoacoustic retinal stimulation technology. We designed a polydimethylsiloxane and carbon-based flexible film that converts near-infrared laser pulses into a localized acoustic field with 56-μm lateral resolution, allowing precise stimulation of mechanosensitive retinal cells. This photoacoustic stimulation robustly and locally modulated retinal ganglion cell activity in both wild-type and degenerated

Identifiers

PMID39282448
PMCPMC11398364

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.