Evidence map›Paper›PMID 39282949›Full record

ArticleeLife2024

Cryo-EM structure of the CBC-ALYREF complex.

Bradley P Clarke, Alexia E Angelos, Menghan Mei, Pate S Hill, Yihu Xie, Yi Ren

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Viral interference of nucleocytoplasmic transport.The Journal of biological chemistry · 2025
    Review
  6. Review
  7. Article
  8. Assembly mechanism of the snRNA nuclear export complex.Nature structural & molecular biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Structures and mRNP remodeling mechanism of the TREX-2 complex.Structure (London, England : 1993) · 2025
    Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bradley P ClarkeDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.ORCID https://orcid.org/0000-0002-9413-9905
Alexia E AngelosDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.
Menghan MeiDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.
Pate S HillDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.ORCID https://orcid.org/0000-0001-9550-2713
Yihu XieDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.
Yi RenDepartment of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville, United States.ORCID https://orcid.org/0000-0003-4531-0910

Funding

Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
Mechanisms and Regulation of Nuclear mRNA ExportR35GM133743 · NIGMS · VANDERBILT UNIVERSITY · PI Yi Ren · 2019 to 2026
$3.6M
mRNA Nuclear Export Machinery as Target of SARS-CoV-2 Nsp1 ProteinR01AI184975 · NIAID · VANDERBILT UNIVERSITY · PI Beatriz MA Fontoura, Adolfo Garcia-Sastre · 2024 to 2026
$2.5M
Thermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0M
NCI NIH HHS T32 CA119925NIAID NIH HHS R01 AI184975NIGMS NIH HHS R35 GM133743NIH HHS R01 AI184975NIH HHS R35 GM133743NIH HHS S10 OD030292NIH HHS T32 CA119925
6 · The paper itself

Abstract

In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5' end with a 7-methylguanosine (m

Indexed as

Cryoelectron MicroscopyHumansNuclear Cap-Binding Protein ComplexProtein BindingProtein ConformationRNA, MessengerNuclear Cap-Binding Protein ComplexRNA, MessengerALYREFcap binding complexhumanmolecular biophysicsmRNA nuclear exportstructural biologyTREX

Identifiers

PMID39282949
PMCPMC11405014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.