Evidence map›Paper›PMID 39283367›Full record

ArticleMolecular biology reports2024

Protective effects of betanin, a novel acetylcholinesterase inhibitor, against H

Zahra Tayarani-Najaran, Mahla Dehghanpour Farashah, Seyed Ahmad Emami, Elham Ramazani, Naghmeh Shahraki, Elham Hadipour

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Can Beetroot (Nutrients · 2025
    Review
  3. Review
  4. Identification of Peptides from EdibleFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zahra Tayarani-NajaranTargeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahla Dehghanpour FarashahMedical Toxicology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Ahmad EmamiDepartment of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Elham RamazaniDepartment of Biology, Yazd University, Yazd, Iran.
Naghmeh ShahrakiMedical Toxicology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Elham HadipourDepartment of Biology, Faculty of Science, University of Guilan, Rasht, Iran. hadipour_e@guilan.ac.ir.

Funding

Halal Research Center IRI, Iran 1-98Mashhad University of Medical Sciences 4001013University of Guilan 57156
6 · The paper itself

Abstract

backgroundDysfunction of the cholinergic system and increased oxidative stress have a crucial role in cognitive disorders including Alzheimer's disease (AD). Here, we have investigated the protective effects of betanin, a novel acetylcholinesterase (AChE) inhibitor, on hydrogen peroxide (H METHODS AND

resultsThe protective effects were assessed by measuring cell viability, the amount of reactive oxygen species (ROS) production, AChE activity, cell damage, and apoptosis using resazurin, 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA), Ellman method, lactate dehydrogenase (LDH) release, propidium iodide (PI) staining and flow cytometry, and Western blot analysis. H

conclusionsOverall, betanin may use the potential to delay or prevent cell death caused by AD through decreasing the activity of AChE as well as attenuating the expression of proteins involved in the apoptosis pathway.

Indexed as

AcetylcholinesteraseApoptosisBetacyaninsCell SurvivalCholinesterase InhibitorsHydrogen PeroxideOxidative StressReactive Oxygen SpeciesAnimalsNeuroprotective AgentsPC12 CellsRatsAcetylcholinesteraseBetacyaninsbetaninCholinesterase InhibitorsHydrogen PeroxideNeuroprotective AgentsReactive Oxygen SpeciesAChE inhibitorApoptosisBetaninCell cultureOxidative stressPC12

Identifiers

PMID39283367

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.