Evidence map›Paper›PMID 39283981›Full record

ArticleInorganic chemistry2024

Mixed Ru(II)-Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

Justin J Ahrens, Madeline Denison, Santana Garcia, Sayak Gupta, Thomas A Kocarek, Irina F Sevrioukova, Claudia Turro, Jeremy J Kodanko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Justin J AhrensDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Madeline DenisonDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Santana GarciaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Sayak GuptaDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Thomas A KocarekInstitute of Environmental Health Sciences, 6135 Woodward Avenue, Integrative Biosciences Center, Room 2126, Wayne State University, Detroit, Michigan 48202, United States.
Irina F SevrioukovaDepartment of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States.ORCID 0000-0002-4498-6057
Claudia TurroDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-3202-5870
Jeremy J KodankoDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States.ORCID 0000-0001-5196-7463

Funding

Toxicological importance of CYP3A4 catalysis and inhibitionR01ES025767 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEVRIOUKOVA, IRINA F · 2016 to 2025
$4.0M
Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase ActivityR01GM098285 · NIGMS · WAYNE STATE UNIVERSITY · PI NGUYEN, HIEN M · 2012 to 2022
$3.5M
Chemistry Biology Interface Training Program at Wayne State UniversityT32GM142519 · NIGMS · WAYNE STATE UNIVERSITY · PI CHOW, CHRISTINE S, PFLUM, MARY KAY H · 2021 to 2025
$1.2M
500 MHz NMR SpectrometerS10OD028488 · OD · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2021 to 2021
$600k
NIEHS NIH HHS R01 ES025767NIGMS NIH HHS R01 GM098285NIGMS NIH HHS T32 GM142519NIH HHS S10 OD028488
6 · The paper itself

Abstract

Cytochrome P450 3A4 (CYP3A4) is a crucial enzyme in human drug metabolism. To garner photochemical control over the inhibition of CYP3A4, a potent Ir(III)-based inhibitor of CYP3A4 was complexed with two Ru(II)-based photocaging groups. Chemical, photochemical, and biological properties of the photocaged inhibitors were characterized. Importantly, mixed Ru(II)-Ir(III) complexes strongly absorb green light, which facilitates the photochemical release of the Ir(III) inhibitor from the Ru(II) caging fragment [Ru(tpy)(Me

Indexed as

Coordination ComplexesCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsIridiumRutheniumAntineoplastic AgentsHumansLightMCF-7 CellsMolecular StructurePhotochemical ProcessesAntineoplastic AgentsCoordination ComplexesCYP3A4 protein, humanCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsIridiumRuthenium

Identifiers

PMID39283981
PMCPMC11458343

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.