Evidence map›Paper›PMID 39284335›Full record

ArticleThe lancet. Healthy longevity2024

SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug?

Pasquale Mone, Michele Ciccarelli, Stanislovas S Jankauskas, Germano Guerra, Carmine Vecchione, Valeria Visco, Gaetano Santulli

Abstract readComment
In one paragraph

Article in The lancet. Healthy longevity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The use of SGLT2 inhibitors in older people: What is important?Aging clinical and experimental research · 2025
    Review
  5. Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pasquale MoneDepartment of Medicine and Health Sciences "Vincenzo Tiberio", Campobasso 86100, Italy; Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY, USA; Casa di Cura Montevergine, Mercogliano (Avellino), Italy. Electronic address: pasquale.mone@unimol.it.
Michele CiccarelliDepartment of Medicine, Surgery, and Dentistry, University of Salerno, Baronissi (Salerno), Italy.
Stanislovas S JankauskasDepartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY, USA.
Germano GuerraDepartment of Medicine and Health Sciences "Vincenzo Tiberio", Campobasso 86100, Italy; International Translational Research and Medical Education Consortium (ITME), Academic Research Unit, Naples, Italy.
Carmine VecchioneDepartment of Medicine, Surgery, and Dentistry, University of Salerno, Baronissi (Salerno), Italy.
Valeria ViscoDepartment of Medicine, Surgery, and Dentistry, University of Salerno, Baronissi (Salerno), Italy.
Gaetano SantulliDepartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY, USA; International Translational Research and Medical Education Consortium (ITME), Academic Research Unit, Naples, Italy; Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.

Funding

Functional role of IP3 receptors in the regulation of cardiac myofibroblastsR01HL146691 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2019 to 2023
$2.1M
Beta Cell Intracellular Calcium and DiabetesR01DK123259 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL146691NIDDK NIH HHS R01 DK123259
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

FrailtyGlucagon-Like Peptide-1 Receptor AgonistsSodium-Glucose Transporter 2 InhibitorsAgedDiabetes Mellitus, Type 2HumansHypoglycemic AgentsGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsSodium-Glucose Transporter 2 Inhibitors

Identifiers

PMID39284335
PMCPMC11472278

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.