Evidence map›Paper›PMID 39284909›Full record

ArticleThe EMBO journal2024

IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat.

Henver S Brunetta, Anna S Jung, Fernando Valdivieso-Rivera, Stepheny C de Campos Zani, Joel Guerra, Vanessa O Furino, Annelise Francisco, Marcelo Berçot, Pedro M Moraes-Vieira, Susanne Keipert and 6 more

Abstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. A planar dimer of bovine ATP synthase.Cell death and differentiation · 2026
    Article
  4. Article
  5. Article
  6. Enzyme Catalytic Parameters and Evolution Across the Dissipation Plane.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Oxidative Phosphorylation in Uncoupled Mitochondria.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Henver S BrunettaDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.
Anna S JungInstitute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0009-0004-0756-8050
Fernando Valdivieso-RiveraObesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0001-5044-197X
Stepheny C de Campos ZaniDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.
Joel GuerraInstitute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Vanessa O FurinoObesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.
Annelise FranciscoDepartment of Pathology, University of Campinas, Campinas, SP, Brazil.
Marcelo BerçotDepartment of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil.
Pedro M Moraes-VieiraDepartment of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0002-8263-786X
Susanne KeipertDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6618-7379
Martin JastrochDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0358-3865
Laurent O MartinezLiMitAging Team, Institute of Metabolic and Cardiovascular Diseases, I2MC UMR1297, IHU HealthAge, INSERM, University of Toulouse, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.ORCID http://orcid.org/0000-0002-0985-3152
Carlos H SpontonObesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.
Roger F CastilhoDepartment of Pathology, University of Campinas, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0003-2338-8717
Marcelo A MoriDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil. morima@unicamp.br.ORCID http://orcid.org/0000-0001-7112-5263
Alexander BarteltInstitute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. alexander.bartelt@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-7840-3991

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 310287/2018-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88881.143924/2017-01Deutsche Forschungsgemeinschaft (DFG) BA4925/2-1Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X3600212EC | European Research Council (ERC) 852742Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2022/00358-1
6 · The paper itself

Abstract

While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis, it remains unclear whether F

Indexed as

Adipose Tissue, BrownATPase Inhibitory ProteinCold TemperatureMitochondrial Proton-Translocating ATPasesThermogenesisAdipocytes, BrownAnimalsEnergy MetabolismHydrolysisMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondriaATPase Inhibitory ProteinMitochondrial Proton-Translocating ATPasesAdipocytesMetabolismMitochondriaThermogenesisUCP1

Identifiers

PMID39284909
PMCPMC11535227

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.