Evidence map›Paper›PMID 39284944›Full record

ArticleCellular and molecular life sciences : CMLS2024

Enhanced complement activation and MAC formation accelerates severe COVID-19.

Calder R Ellsworth, Zheng Chen, Mark T Xiao, Chaosi Qian, Chenxiao Wang, Mst Shamima Khatun, Shumei Liu, Mohammad Islamuddin, Nicholas J Maness, Jose A Halperin and 4 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. SARS-CoV-2 seeds IAPP aggregation and β-cell failure.Signal transduction and targeted therapy · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Calder R EllsworthTulane National Primate Research Center, Covington, LA, 70433, USA.
Zheng ChenTulane National Primate Research Center, Covington, LA, 70433, USA.
Mark T XiaoTulane National Primate Research Center, Covington, LA, 70433, USA.
Chaosi QianDepartment of Microbiology and Immunology, Medical University of South Carolina, and Ralph Johnson VA Medical Center, Charleston, SC, USA.
Chenxiao WangTulane National Primate Research Center, Covington, LA, 70433, USA.
Mst Shamima KhatunDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Shumei LiuTulane National Primate Research Center, Covington, LA, 70433, USA.
Mohammad IslamuddinTulane National Primate Research Center, Covington, LA, 70433, USA.
Nicholas J ManessTulane National Primate Research Center, Covington, LA, 70433, USA.
Jose A HalperinDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Robert V BlairTulane National Primate Research Center, Covington, LA, 70433, USA.
Jay K KollsDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Stephen TomlinsonDepartment of Microbiology and Immunology, Medical University of South Carolina, and Ralph Johnson VA Medical Center, Charleston, SC, USA.
Xuebin QinTulane National Primate Research Center, Covington, LA, 70433, USA. xqin2@tulane.edu.ORCID http://orcid.org/0000-0001-9875-983X

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
Role of Complement Activation in Severe COVID-19R01HL165265 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QIN, XUEBIN · 2022 to 2025
$2.9M
Renal Macrophage BiologyR01DK129881 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Xuebin Qin · 2022 to 2026
$2.5M
Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular ReactivityR21NR010361 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WIPKE-TEVIS, DEIDRE D · 2008 to 2009
$401k
American Heart Association AHA962950American Heart Association-American Stroke Association 962950BLRD VA IK6 BX005235NHLBI NIH HHS R01 HL165265NHLBI NIH HHS R35 HL139930NIDDK NIH HHS R01 DK129881NIH HHS HL139930NIH HHS P51 OD011104NIH HHS P51OD011104-62NIH HHS R01DK129881NIH HHS R01HL165265NINR NIH HHS R21 NR010361U.S. Department of Veterans Affairs IK6BX005235
6 · The paper itself

Abstract

Emerging evidence indicates that activation of complement system leading to the formation of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However, their pathogenic roles have never been experimentally investigated before. We used three knock out mice strains (1. C3

Indexed as

CD59 AntigensComplement ActivationComplement Membrane Attack ComplexCOVID-19Mice, KnockoutSARS-CoV-2AnimalsComplement C3Complement C5Disease Models, AnimalHumansMiceMice, Inbred C57BLCD59 AntigensComplement C3Complement C5Complement Membrane Attack ComplexC3Cd59ComplementEndothelial dysfunctionMACSevere COVID-19

Identifiers

PMID39284944
PMCPMC11405604

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.