ReviewNature aging2024
Challenges and recommendations for the translation of biomarkers of aging.
Abstract readReview
In one paragraph
Review in Nature aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemical and climatic environmental exposures and epigenetic aging: A systematic review.Environmental research · 2025Pooled it
- Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults.Journal of cachexia, sarcopenia and muscle · 2026Article
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Biomarkers of Inflammaging and Cellular Senescence in Musculoskeletal (MSK) Diseases: The Knowns and the Unknowns.Biomedicines · 2026Article
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- Advanced drug delivery platforms targeting cellular senescence: A promising strategy for cancer therapy.Acta pharmaceutica Sinica. B · 2026Review
- Article
- Robustness in Older Adults: A Concept Analysis Using Rodgers' Evolutionary Approach.Nursing & health sciences · 2026Review
- Skin as a sentinel and modulator of systemic aging: a translational framework for evidence-based gerotherapeutics.GeroScience · 2026Review
- Moving beyond cancer survivorship: longevity medicine.BMJ supportive & palliative care · 2026Article
- Face aging rate quantifies change in biological age to predict cancer outcomes.Nature communications · 2026Article
- An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease.Aging cell · 2026Article
- Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: From Molecular Mechanisms to Preclinical Studies.Molecular neurobiology · 2026Review
- Community threat, positive parenting, and accelerated epigenetic aging: Longitudinal links from childhood to adolescence.Child development · 2026Article
- Challenges and Opportunities in Multi-Omics Data Acquisition and Analysis: Toward Integrative Solutions.Biomolecules · 2026Review
- Alcohol Consumption and DNA Methylation in a Mediterranean Cohort: A Focus on Oxidative Stress and Aging Biomarkers.Antioxidants (Basel, Switzerland) · 2026Article
- Toward new clinical evaluation models for skin longevity: the need for predictive and accelerated approaches.GeroScience · 2026Article
- Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank.GeroScience · 2026Article
- Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Biomarkers of Aging Consortium
Chiara M S Herzog *European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-1572-498X
Ludger J E Goeminne *Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8285-7766
Jesse R Poganik *Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3098-8550
Nir BarzilaiInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Daniel W BelskyDepartment of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-5463-2212
Joe Betts-LaCroixRetro Biosciences, Inc, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6823-5207
Brian H ChenSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Michelle ChenInsilico Medicine, Cambridge, MA, USA.
Alan A CohenDepartment of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4113-3988
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8808-260X
Peter O FedichevGero PTE Ltd, Singapore, Singapore.
Luigi FerrucciNational Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6273-1613
Alexander FlemingKinexum LLC, Harpers Ferry, WV, USA.
Kristen FortneyBioAge Labs, Richmond, CA, USA.
David FurmanBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0002-3654-9519
Vera GorbunovaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Albert Higgins-ChenDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2904-2741
Lee HoodBuck Institute for Research on Aging, Novato, CA, USA.
Steve HorvathAltos Labs, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-4110-3589
Jamie N JusticeXPRIZE Foundation, Culver City, CA, USA.ORCID http://orcid.org/0000-0003-2953-4404
Douglas P KielHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, USA.ORCID http://orcid.org/0000-0001-8474-0310
George A KuchelUniversity of Connecticut School of Medicine, @UConnAging, Farmington, CT, USA.ORCID http://orcid.org/0000-0001-8387-7040
Jessica Lasky-SuDepartment of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6236-4705
Nathan K LeBrasseurDepartment of Physical Medicine and Rehabilitation, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2002-0418
Andrea B MaierHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0001-7206-1724
Birgit SchillingBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-9907-2749
Vittorio SebastianoDepartment of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8498-8655
P Eline SlagboomSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-2875-4723
Michael P SnyderDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0784-7987
Eric VerdinBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0003-3703-3183
Martin WidschwendterEuropean Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
Alex ZhavoronkovInsilico Medicine, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7067-8966
Mahdi MoqriDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6675-0566
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@rics.bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0372-7016
Funding
The effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MSenescent cell mapping, identification and validation for human somatic and reproductive tissuesU54AG075932 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Simon Melov, Birgit Schilling · 2021 to 2026
$12.5MResearch Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5MIntegrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0MThe role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2MQUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONSR01AG065403 · NIA · YALE UNIVERSITY · PI Vadim N. Gladyshev, Albert Tzongyang Higgins-Chen · 2020 to 2026
$4.2MQuantitative Proteomics to Develop Robust Senescence-Related Biomarkers for AgingU01AG060906 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI SCHILLING, BIRGIT · 2018 to 2022
$4.0MRole of rare damaging mutations in agingR01AG064223 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2020 to 2024
$2.8MProfiling epigenetic age in single cells and in a high-throughput mannerR56AG076607 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2022 to 2022
$310kNHLBI NIH HHS R01 HL123915NIAID NIH HHS P01 AI153559NIA NIH HHS P30 AG067988NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG064223NIA NIH HHS R01 AG065403NIA NIH HHS R56 AG076607NIA NIH HHS U01 AG060906NIA NIH HHS U54 AG075932U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG064223U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG065403U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG076607
Abstract
Biomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings. We surveyed experts in these areas to better understand current challenges for the translation of aging biomarkers. We identified six key barriers to clinical translation and developed guidance for the field to overcome them. Core recommendations include linking BOA to clinically actionable insights, improving affordability and availability to broad populations and validation of biomarkers that are robust and responsive at the level of individuals. Our work provides key insights and practical recommendations to overcome barriers impeding clinical translation of BOA.
Indexed as
AgingBiomarkersTranslational Research, BiomedicalHumansBiomarkers
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.