ArticleCancer communications (London, England)2024
Local TSH/TSHR signaling promotes CD8
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Article in Cancer communications (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Small Extracellular Vesicles-Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer.Clinical and translational medicine · 2026Review
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Thyroid-stimulating hormone receptor mediates peripheral-central neuroimmune crosstalk in autoimmune thyroid diseases.BMC medicine · 2026Article
- PRELID1 and VDAC3 Coordinate a Senescence-Like State in Germinal Center B Cells to Promote IL-7-Driven Antitumor Immunity in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- METTL16-mediated m6A modification of LYRM2 drives breast cancer progression by inducing CD8Journal of bioenergetics and biomembranes · 2026Article
- Single-cell analysis reveals the prognostic role of immune escape in the colorectal cancer microenvironment.Translational cancer research · 2026Article
- Hyperglycemia drives lmmune evasion in colorectal cancer through VISTA stabilization.Cell communication and signaling : CCS · 2026Article
- Exposure to multiple metallic elements and risk of thyroid tumors: insights from elemental profiling, diet, and molecular characteristics plasma levels of metallic elements.Frontiers in oncology · 2026Article
- Post-Translational Modifications in Cancer-Associated CD8⁺ T-Cell Exhaustion: Mechanisms and Therapeutic Opportunities.International journal of biological sciences · 2026Review
- Mapping Current Research Status and Emerging Frontiers of T-Cell Exhaustion: A Comprehensive Data-Mining-Based Study.Annals of surgical oncology · 2026Article
- A SENP7-SIRT1-IL-10 Axis Driven by DeSUMOylation Promotes Breg Differentiation and Immune Evasion in Colorectal Cancer.International journal of biological sciences · 2026Article
- Extracellular vesicles cargo orchestration in colorectal cancer: immune evasion, stromal remodeling, and therapeutic frontiers.Molecular cancer · 2025Review
- TSH Ligand-Based CAR-T Cell Effectively Eradicates TSHR-Positive Thyroid Cancer with Favorable Safety Profile.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A novel biomimetic nanoplatform amplifies ferroptosis for specific cGAS-STING pathway activation to enhance hepatocellular carcinoma chemo-immunotherapy.Journal of nanobiotechnology · 2025Article
- Review
- The neuro-immune axis in cancer: from mechanisms to therapeutic opportunities.Journal of hematology & oncology · 2025Review
- In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors.bioRxiv : the preprint server for biology · 2025Article
- Machine learning integration of bulk and single-cell RNA-seq data reveals glycolytic heterogeneity in colorectal cancer.Medical oncology (Northwood, London, England) · 2025Article
- TSHR in thyroid cancer: bridging biological insights to targeted strategies.European thyroid journal · 2025Review
Corrections and comments
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Authors and funding
22 authors.
Sisi ZengDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Huiling HuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Zhiyang LiDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Qi HuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Rong ShenDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Mingzhou LiDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Yunshi LiangDepartment of Pathology, Guangzhou First People's Hospital, Guangzhou, Guangdong, P. R. China.
Zuokang MaoDepartment of Hepatobiliary Surgery, The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong, P. R. China.
Yandong ZhangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Wanqi ZhanDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Qin ZhuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Feifei WangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Jianbiao XiaoDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Bohan XuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Guanglong LiuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Yanan WangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Bingsong LiDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Shaowan XuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Zhaowen ZhangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Ceng ZhangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Zhizhang WangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Li LiangDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.ORCID 0000-0003-2424-4926
Funding
National Key Research and Development Program of China 2021YFF1201004National Natural Science Foundation of China 32270926National Natural Science Foundation of China 81802306National Natural Science Foundation of China 81872041National Natural Science Foundation of China 81903002National Natural Science Foundation of China 82071742National Natural Science Foundation of China 82273358Natural Science Foundation of Guangdong Province 2019A1515012196Natural Science Foundation of Guangdong Province 2022A1515012059
Abstract
backgroundDysfunction of CD8
methodsTSHR expression levels in CD8
resultsTSHR was highly expressed in cancer cells and CD8
conclusionsThe present findings highlighted the role of endogenous TSH/TSHR signaling in CD8
Indexed as
CD8-Positive T-LymphocytesColorectal NeoplasmsReceptors, ThyrotropinSignal TransductionThyrotropinTumor MicroenvironmentAnimalsCell Line, TumorHumansMiceT-Cell ExhaustionTumor EscapeReceptors, ThyrotropinThyrotropinCD8+ T cell exhaustionColorectal carcinomaImmune evasionThyroid stimulating hormoneThyroid stimulating hormone receptor
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.