Evidence map›Paper›PMID 39288028›Full record

ArticleCell reports2024

Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.

Shinya Ito, Alex Piet, Corbett Bennett, Séverine Durand, Hannah Belski, Marina Garrett, Shawn R Olsen, Anton Arkhipov

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shinya ItoAllen Institute, Seattle, WA, USA. Electronic address: shinya.ito@alleninstitute.org.
Alex PietAllen Institute for Neural Dynamics, Seattle, WA, USA.
Corbett BennettAllen Institute for Neural Dynamics, Seattle, WA, USA.
Séverine DurandAllen Institute for Neural Dynamics, Seattle, WA, USA.
Hannah BelskiAllen Institute for Neural Dynamics, Seattle, WA, USA.
Marina GarrettAllen Institute for Neural Dynamics, Seattle, WA, USA.
Shawn R OlsenAllen Institute for Neural Dynamics, Seattle, WA, USA.
Anton ArkhipovAllen Institute, Seattle, WA, USA. Electronic address: antona@alleninstitute.org.

Funding

Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical NeuronsU01MH130907 · NIMH · ALLEN INSTITUTE · PI ANTON ARKHIPOV, MARINA E. GARRETT · 2022 to 2026
$12.5M
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory EntrainmentR01NS122742 · NINDS · ALLEN INSTITUTE · PI ANTON ARKHIPOV, Li-Huei Tsai · 2021 to 2026
$4.1M
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data FormatU24NS124001 · NINDS · ALLEN INSTITUTE · PI ANTON ARKHIPOV, Emad Tajkhorshid · 2021 to 2026
$3.4M
Modeling the structure-function relation in a reconstructed cortical tissueR01EB029813 · NIBIB · ALLEN INSTITUTE · PI ARKHIPOV, ANTON, MIHALAS, STEFAN · 2020 to 2020
$1.3M
NIBIB NIH HHS R01 EB029813NIMH NIH HHS U01 MH130907NINDS NIH HHS R01 NS122742NINDS NIH HHS U24 NS124001
6 · The paper itself

Abstract

Recent studies have found dramatic cell-type-specific responses to stimulus novelty, highlighting the importance of analyzing the cortical circuitry at this granularity to understand brain function. Although initial work characterized activity by cell type, the alterations in cortical circuitry due to interacting novelty effects remain unclear. We investigated circuit mechanisms underlying the observed neural dynamics in response to novel stimuli using a large-scale public dataset of electrophysiological recordings in behaving mice and a population network model. The model was constrained by multi-patch synaptic physiology and electron microscopy data. We found generally weaker connections under novel stimuli, with shifts in the balance between somatostatin (SST) and vasoactive intestinal polypeptide (VIP) populations and increased excitatory influences on parvalbumin (PV) and SST populations. These findings systematically characterize how cortical circuits adapt to stimulus novelty.

Indexed as

SomatostatinAnimalsCerebral CortexMiceModels, NeurologicalNerve NetNeuronsParvalbuminsSynapsesVasoactive Intestinal PeptideParvalbuminsSomatostatinVasoactive Intestinal Peptidecell typescomputational neuroscienceCP: Neurosciencemousenetwork modelingnoveltyprimary visual cortexstabilized supralinear networkvisual behavior

Identifiers

PMID39288028
PMCPMC11563561

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.