ArticleJournal of affective disorders2025
Neuroticism, loneliness, all-cause and cause-specific mortality: A 17-year study of nearly 500,000 individuals.
Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Loneliness and Hikikomori Symptoms. A Systematic Review and Meta-Analysis.International journal of methods in psychiatric research · 2026Pooled it
- Personality nuances and inflammation: A coordinated analysis of six samples.Psychoneuroendocrinology · 2026Pooled it
- Loneliness and Personality: Noise- and Bias-Free True Correlations Between Loneliness and the Big Five Personality Domains.Journal of personality · 2026Article
- [Quality of relationships among the oldest old in Germany-an examination of the association with depressive symptoms and loneliness].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Article
- Gaming disorder: Prevalence and association with psychosocial outcomes in the German general adult population.Addictive behaviors reports · 2026Article
- Mindfulness as a mediator and moderator between interpersonal alienation and smartphone addiction among Taiwanese university students.BMC psychology · 2026Article
- Are Individuals Aged 80+ Providing Great-Grandchild Care More Satisfied With Their Lives and Less Lonely? Findings Based on a Nationwide Representative Sample.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Association of loneliness and perceived social exclusion with donation behavior among community-dwelling individuals aged 40 and over: longitudinal evidence from the nationally representative German Ageing Survey.Aging clinical and experimental research · 2026Observational
- Association of mainly vegetarian and vegan diets with loneliness, social isolation and social withdrawal in a German population survey.PloS one · 2026Article
- Beyond words: the association of hugging with loneliness, social isolation, and social withdrawal. Evidence from the general adult population in Germany based on a cross-sectional survey.Frontiers in public health · 2026Article
- Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study.Frontiers in psychiatry · 2026Article
- How is the Beginning and End of Frequent Laughter Associated With Changes in Loneliness Amongst Older People in Japan? A JAGES Longitudinal Study.International journal of geriatric psychiatry · 2025Article
- Estimated glucose disposal rate and the dynamic transitions of cardiometabolic multimorbidity and all-cause mortality in prediabetes: a multistate trajectory analysis.Lipids in health and disease · 2025Article
- Loneliness and isolation: Are they associated with the wish for an earlier end of life?Geriatrics & gerontology international · 2025Article
- How Is One's Own and (Ex-)Partner's Professional Prestige Associated With Loneliness and Isolation? Findings Based on Cross-Sectional Data From Middle-Aged and Older Adults Living in Germany in 2022/2023.Health science reports · 2025Article
- Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Personality nuances and mortality risk: A coordinated analysis of four longitudinal samples.Journal of psychosomatic research · 2025Article
- Association of professional environment with loneliness and perceived social isolation among individuals in their second half of life.Aging clinical and experimental research · 2025Article
- Personality traits and loneliness: An ecological momentary assessment study with self and partner ratings.Journal of research in personality · 2025Article
- Loneliness Links Adverse Childhood Experiences to Mortality Risk Across 26 Years.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundNeuroticism is related to mental and physical health. This study examined whether neuroticism and its underlying components were associated with risk of all-cause and cause-specific mortality.
methodsCommunity-dwelling adults (N = 491,323) in the UK Biobank completed a neuroticism scale between 2006 and 2010. Vital status was tracked up to December 2022 via linkage with the UK National Health Service.
resultsOver 17 years of follow-up, 43,400 (8.8 %) participants died. Accounting for age, sex, and ethnicity, participants who scored 1 SD higher on neuroticism had a 10 % greater risk of dying (HR = 1.10, 95%CI = 1.09-1.11), an association that remained significant but was explained partly by socioeconomic status, health behaviors, and chronic conditions. Item-level analyses found that loneliness was the neuroticism item most predictive of mortality (HR = 1.46, 95%CI = 1.43-1.49), especially in males. Neuroticism and loneliness were more predictive of mortality among relatively younger adults and those with lower education. Among the causes of death, neuroticism and loneliness had the strongest association with deaths due to intentional self-harm, respiratory and digestive system diseases. LIMITATIONS: Loneliness was assessed with a single item. The associations could be due to increases in neuroticism and loneliness approaching death. However, contrary to expectations from reverse causality, the associations were similar when excluding deaths within the first five or ten years of follow-up. Future research should examine whether findings from this high-income country replicate in middle- and lower-income communities.
conclusionsLoneliness was the component of neuroticism most strongly associated with premature mortality, including from intentional self-harm, respiratory, and digestive system causes of death.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.