ArticleJournal of neurology, neurosurgery, and psychiatry2025
Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Speech Biomarkers for Quantifying Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease.Annals of neurology · 2026Article
- Mapping Postictal Aphasia through Signal Complexity: A Stereo-Electroencephalography Study.Annals of neurology · 2025Article
- Left hemisphere lateralization in unilateral upper motor neuron dysarthria via quantitative acoustic analysis.Scientific reports · 2025Article
- Effects of different side motor impairments at early onset on voice acoustic performance in patients with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere.
methodsAcoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT).
resultsFrom a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01).
conclusionOur data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.
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