Evidence mapPaperPMID 39289716Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2024

Immune-related [

Giulia Santo, Maria Cucè, Antonino Restuccia, Teresa Del Giudice, Pierfrancesco Tassone, Francesco Cicone, Pierosandro Tagliaferri, Giuseppe Lucio Cascini

Abstract read
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Review
  3. Early-time-pointRadiology and oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulia SantoNuclear Medicine Unit, Department of Experimental and Clinical Medicine, "Mater Domini" University Hospital, "Magna Graecia" University, Catanzaro, Italy.
Maria CucèMedical Oncology Unit, "Mater Domini" University Hospital, Catanzaro, Italy.
Antonino RestucciaNuclear Medicine Unit, "Mater Domini" University Hospital, Catanzaro, Italy.
Teresa Del GiudiceMedical Oncology Unit, "Pugliese Ciaccio" Hospital, Catanzaro, Italy.
Pierfrancesco TassoneTranslational Medical Oncology Unit, Department of Experimental and Clinical Medicine, "Mater Domini" University Hospital, "Magna Graecia" University, Catanzaro, Italy.
Francesco Cicone *Nuclear Medicine Unit, Department of Experimental and Clinical Medicine, "Mater Domini" University Hospital, "Magna Graecia" University, Catanzaro, Italy. cicone@unicz.it.
Pierosandro Tagliaferri *Medical Oncology Unit, Department of Experimental and Clinical Medicine, "Mater Domini" University Hospital, "Magna Graecia" University, Catanzaro, Italy.
Giuseppe Lucio Cascini *Nuclear Medicine Unit, Department of Experimental and Clinical Medicine, "Mater Domini" University Hospital, "Magna Graecia" University, Catanzaro, Italy.

Funding

European Union Next-GenerationEU - National Recovery and Resilience Plan (NRRP) MISSION 4 COMPONENT 1, INVESTMENT 4.1 - D.M. 351 09/04/2022European Union Next-GenerationEU NRRP Research Projects of National Interest (PRIN), Italian Ministry for University and Research (MUR), project 2022Z4KJ48
6 · The paper itself

Abstract

backgroundDirect comparisons between [

methodsFifty-one patients with melanoma (47%) or NSCLC (53%) undergoing multiple PET examinations during anti-PD1/PDL1 treatment were retrospectively included. Clinical irAEs were graded according to CTCAE v.5.0. Abnormal PET findings suggestive of immune activation were described by two readers blinded to the clinical data. Progression-free survival (PFS) and overall survival (OS) were analyzed with the Kaplan-Meier method in patients stratified according to the presence of irAEs, immune-related PET findings or both.

resultsTwenty-one patients showed clinical irAEs only (n = 6), immune-related PET findings only (n = 6), or both (n = 9). In patients whose imaging findings corresponded to clinical irAEs (n = 7), a positive correlation between SUV

conclusionPatients with melanoma or NSCLC under ICI treatment can develop clinical irAEs, immune-related PET findings, or both. The occurrence of immune-related events has a prognostic impact. Combining clinical information with PET assessment improved outcome stratification.

Indexed as

Carcinoma, Non-Small-Cell LungFluorodeoxyglucose F18Immune Checkpoint InhibitorsMelanomaPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAdultAgedAged, 80 and overFemaleHumansLung NeoplasmsMaleMiddle AgedPrognosisRetrospective StudiesFluorodeoxyglucose F18Immune Checkpoint InhibitorsRadiopharmaceuticalsAnti-PD1/PDL1FDG PETImmune checkpoint inhibitorsImmune-related adverse eventsPrognosis

Identifiers

PMID39289716
PMCPMC11409779

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.