Evidence map›Paper›PMID 39291493›Full record

ArticleJournal of the American Heart Association2024

Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Francesca Cendali, Angelo D'Alessandro, S M Shafiqul Alam, Victor Garcia, Joseph M Miano and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Vascular Remodeling: The Multicellular Mechanisms of Pulmonary Hypertension.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina SignorettiDepartment of Pharmacology New York Medical College Valhalla NY USA.
Shun MatsumuraDepartment of Pharmacology New York Medical College Valhalla NY USA.
Samuel FatehiDepartment of Pharmacology New York Medical College Valhalla NY USA.
Melinee D'SilvaDepartment of Pharmacology New York Medical College Valhalla NY USA.ORCID 0000-0001-6921-7046
Rajamma MathewDepartment of Medicine, Division of Pediatric Cardiology, Physiology New York Medical College Valhalla NY USA.
Francesca CendaliDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora CO USA.ORCID 0000-0002-8874-2150
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora CO USA.
S M Shafiqul AlamDepartment of Pathology, Microbiology, and Immunology (PMI) New York Medical College Valhalla NY USA.
Victor GarciaDepartment of Pharmacology New York Medical College Valhalla NY USA.ORCID 0000-0002-1849-8834
Joseph M MianoDepartment of Medicine Vascular Biology Center, Medical College of Georgia at Augusta University Augusta GA USA.ORCID 0000-0001-7522-3207
Sachin A GupteDepartment of Pharmacology New York Medical College Valhalla NY USA.ORCID 0000-0001-7453-8303

Funding

Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL166546 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SACHIN A GUPTE, Joseph M Miano · 2023 to 2026
$2.7M
Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
GPR75 in obesity-driven cardiovascular and metabolic complicationsR01HL168056 · NHLBI · NEW YORK MEDICAL COLLEGE · PI Michal Laniado Schwartzman · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL132574NHLBI NIH HHS R01 HL166546NHLBI NIH HHS R01 HL168056
6 · The paper itself

Abstract

backgroundG6PD (glucose-6-phosphate-dehydrogenase) is a key enzyme in the glycolytic pathway and has been implicated in the pathogenesis of cancer and pulmonary hypertension-associated vascular remodeling. Here, we investigated the role of an X-linked METHODS AND

resultsCRISPR-Cas9 genome editing was used to generate the

conclusionsOur results suggest G6PD

Indexed as

Glucosephosphate DehydrogenaseReceptors, Vascular Endothelial Growth FactorAnimalsDisease Models, AnimalHypertension, PulmonaryHypertrophy, Right VentricularIndolesMalePulmonary ArteryPyrrolesRatsRats, Sprague-DawleyVascular RemodelingGlucosephosphate DehydrogenaseIndolesPyrrolesReceptors, Vascular Endothelial Growth FactorSemaxinibmetabolic reprogrammingNOS3PAI‐1pulmonary hypertensionSerpine1thrombosisvascular remodeling

Identifiers

PMID39291493
PMCPMC11681449

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.