Evidence map›Paper›PMID 39293511›Full record

ArticleJournal of global antimicrobial resistance2024

Synthetic lincosamides iboxamycin and cresomycin are active against ocular multidrug-resistant methicillin-resistant Staphylococcus aureus carrying erm genes.

Camille André, Kelvin J Y Wu, Andrew G Myers, Paulo J M Bispo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of global antimicrobial resistance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Camille AndréDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MA, USA.
Kelvin J Y WuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Andrew G MyersDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Paulo J M BispoDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MA, USA. Electronic address: paulo_bispo@meei.harvard.edu.

Funding

Discovery through chemical synthesis of antibiotics effective against modern bacterial pathogensR01AI168228 · NIAID · HARVARD UNIVERSITY · PI ANDREW G MYERS · 2022 to 2026
$3.8M
NIAID NIH HHS R01 AI168228
6 · The paper itself

Abstract

objectiveAntimicrobial resistance is a global pandemic that poses a major threat to vision health as ocular bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), are becoming increasingly resistant to first-line therapies. Here we evaluated the antimicrobial activity of new synthetic lincosamides in comparison to currently used antibiotics against clinical ocular MRSA isolates.

methodsAntimicrobial susceptibility testing was performed by broth microdilution for two novel synthetic lincosamides (iboxamycin and cresomycin) and eight comparator antibiotics against a collection of 50 genomically characterised ocular MRSA isolates, including isolates harbouring erm genes (n = 25).

resultsBoth drugs were active against widespread MRSA clonal complexes CC8 and CC5. The MIC

conclusionsOur results demonstrate that iboxamycin and cresomycin display potent in vitro activity against ocular MRSA isolates, including multidrug-resistant isolates harbouring erm genes.

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialLincosamidesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsBacterial ProteinsBridged-Ring CompoundsHumansMethyltransferasesOxepinsStaphylococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsBridged-Ring CompoundscresomycinLincosamidesMethyltransferasesOxepinsErm genesMRSAMultidrug resistanceNew antibiotics

Identifiers

PMID39293511
PMCPMC11771510

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.