Evidence map›Paper›PMID 39294236›Full record

ArticleScientific reports2024

Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population.

Yongfeng Pei, Haibin Li, Chengxin Huang, Yinhong Qin, Xuyong Sun

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yongfeng Pei *School of Basic Medicine, Guangxi Medical University, Nanning, China.
Haibin Li *Institute of Transplantation Medicine, The Second Affiliated Hospital of Guangxi Medical University. Guangxi Clinical Research Center for Organ Transplantation. Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning, China.
Chengxin HuangInstitute of Transplantation Medicine, The Second Affiliated Hospital of Guangxi Medical University. Guangxi Clinical Research Center for Organ Transplantation. Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning, China.
Yinhong QinInstitute of Transplantation Medicine, The Second Affiliated Hospital of Guangxi Medical University. Guangxi Clinical Research Center for Organ Transplantation. Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning, China.
Xuyong SunInstitute of Transplantation Medicine, The Second Affiliated Hospital of Guangxi Medical University. Guangxi Clinical Research Center for Organ Transplantation. Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning, China. sunxuyong@gxmu.edu.cn.

Funding

the National Natural Science Foundation of China 81670596
6 · The paper itself

Abstract

To investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325 patients with ESRD and genotyped the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci. The direct counting method was used to determine the frequencies of HLA alleles, and Arlequin software (version 3.5.2.2) was used for haplotypic frequency analyses to compare the included ESRD patients with 350 healthy donors from the Guangxi Zhuang population. In our study, 120 HLA alleles, 284 HLA-A-B-DRB1 haplotypes, and 332 HLA-A-C-B-DRB1-DQB1 haplotypes were detected. We found that only A*11:01-B*15:02-DRB1*12:02 had a positive association with ESRD (P = 0.001, P

Indexed as

Gene FrequencyGenetic Predisposition to DiseaseHLA AntigensKidney Failure, ChronicAdultAgedAllelesCase-Control StudiesChinaEast Asian PeopleFemaleHaplotypesHumansMaleMiddle AgedPolymorphism, GeneticHLA AntigensAllele frequencyEnd stage renal diseaseGuangxi Zhuang populationHaplotypeHLA

Identifiers

PMID39294236
PMCPMC11410959

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.