ArticleNature cardiovascular research2024
Cardiac NAD
Abstract read
In one paragraph
Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Article
- Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease.International journal of molecular sciences · 2026Review
- Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026Review
- Explainable machine learning-driven identification of heart failure biomarkers: a multi-model feature selection approach with SHAP-based interpretability.Scientific reports · 2026Article
- NAMPT Deficiency Promotes Endothelial-Mesenchymal Transition by Inhibiting Energy Metabolism and Lysosomal Acidification in Late-Onset Fuchs Endothelial Corneal Dystrophy.Investigative ophthalmology & visual science · 2026Article
- Vitamin B3 rescues mitochondrial homeostasis in dexamethasone-induced skeletal muscle atrophy by reducing oxidative stress.Journal of bioenergetics and biomembranes · 2026Article
- High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoEMolecular medicine reports · 2026Article
- Beyond Leptin and Adiponectin: The Diverse Roles of Adipokines in the Myocardial Hypertrophic Process and Heart Failure and Their Potential Contribution in Obesity.International journal of molecular sciences · 2025Review
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.Cardiovascular diabetology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Khanh V Doan *Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7251-3599
Timothy S Luongo *Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thato T Ts'oloDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Won Dong LeeLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-2344-171X
David W FrederickDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sarmistha MukherjeeDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3258-0287
Gabriel K AdzikaDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4827-7266
Caroline E PerryDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ryan B GasparDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7922-3893
Nicole WalkerDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Megan C BlairDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nicole ByeDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James G DavisDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Corey D HolmanDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1111-7442
Qingwei ChuDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lin WangLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1247-4727
Daniel P KellyDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3811-9491
Thomas P CappolaDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kenneth B MarguliesDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8093-4465
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8262-6549
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA D RABINOWITZ · 1986 to 2026
$48.3MREGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6MNRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0MTumor cell metabolism in actionR01CA163591 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI JOSHUA D RABINOWITZ, Eileen P. White · 2012 to 2026
$7.0MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MMetabolism in Action: Quantitative Fluxes in MammalsDP1DK113643 · NIDDK · PRINCETON UNIVERSITY · PI RABINOWITZ, JOSHUA D · 2016 to 2020
$5.7MTraining in Muscle Biology and Muscle DiseaseT32AR053461 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI OSTAP, E. MICHAEL · 2006 to 2025
$4.9MMTSS1 in Myocardial DiseaseR01HL141232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Scott Michael Damrauer · 2019 to 2026
$4.7MUnderstanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7MIndirect calorimetry cages equipped for glucose and blood pressure telemetryS10OD025098 · OD · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2019 to 2019
$750kImpact of insulin on lactate metabolismF32DK127843 · NIDDK · PRINCETON UNIVERSITY · PI LEE, WON DONG · 2021 to 2023
$208kFoundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) DP1DK113643Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) F32DK127843Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) F32HL145923Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01CA163591Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01HL058493Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01HL128349Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01HL141232Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) S10-OD025098Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) T32AR53461Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) TL1TR001880NCATS NIH HHS TL1 TR001880NCI NIH HHS R01 CA163591NHLBI NIH HHS F32 HL145923NHLBI NIH HHS R01 HL058493NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL141232NHLBI NIH HHS R01 HL165792NIAMS NIH HHS T32 AR053461NIDDK NIH HHS DP1 DK113643NIDDK NIH HHS F32 DK127843NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK098656NIH HHS S10 OD025098
Abstract
Nicotinamide adenine dinucleotide (NAD
Indexed as
Arrhythmias, CardiacCardiomyopathy, HypertrophicEnergy MetabolismMyocytes, CardiacNADNicotinamide PhosphoribosyltransferaseAnimalsCytokinesDeath, Sudden, CardiacDisease Models, AnimalElectrocardiographyMaleMiceMice, Inbred C57BLMice, KnockoutNiacinamideCytokinesNADNiacinamidenicotinamide-beta-ribosideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mousePyridinium Compounds
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.