ArticleEMBO reports2024
miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.
Abstract read
In one paragraph
Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- In vivo AGO-APP for cell-type- and compartment-specific miRNA profiling in the mouse brain.Cell reports methods · 2026Article
- Is the Activation of the Postsynaptic Ligand Gated Glycine- or GABABiomedicines · 2025Review
- Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity.Current opinion in neurobiology · 2025Review
Corrections and comments
- Update of
Authors and funding
12 authors.
Theresa M Welle *Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0001-6138-240X
Dipen Rajgor *Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.
Dean J KareemoDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0002-9575-0407
Joshua D GarciaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0002-7572-2062
Sarah M ZychDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.
Sarah E WolfeDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0003-0922-3406
Sara E GookinDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0001-8830-118X
Tyler P MartinezDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0002-2136-4933
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0003-3798-3461
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0002-4175-2933
Matthew J KennedyDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA.ORCID 0000-0002-7029-7802
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO, 80045, USA. katharine.r.smith@cuanschutz.edu.ORCID 0000-0002-4762-7201
Funding
Novel approaches for interrogating and manipulating synaptic function, structure and plasticityR35NS116879 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Matthew J Kennedy · 2020 to 2026
$4.0MEncoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5MRegulation of striatal acetylcholine transmission by cholinergic interneuronsR01NS095809 · NINDS · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2016 to 2024
$3.4ML-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription CouplingR01MH123700 · NIMH · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2021 to 2025
$2.8MLocal translation mechanisms to control inhibitory synaptic plasticityR01MH128199 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2022 to 2025
$2.5MNeuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1MNanoscale organization of the inhibitory synapse during synaptic plasticityR01MH119154 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2020 to 2024
$2.0MMapping somatodendritic circuits of midbrain dopamine neuronsF30DA048543 · NIDA · UNIVERSITY OF COLORADO DENVER · PI ZYCH, SARAH · 2019 to 2022
$156kInvestigating the synaptic trafficking of endogenous AMPARsF31NS130979 · NINDS · UNIVERSITY OF COLORADO DENVER · PI KAREEMO, DEAN · 2023 to 2025
$93kUnderstanding the temporal regulation of inhibitory synapse depression and elimination in the context of cerebral ischemiaF99NS120640 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GARCIA, JOSHUA DAYLON · 2021 to 2022
$72kHHS | NIH | National Institute of Mental Health (NIMH) R01MH119154HHS | NIH | National Institute of Mental Health (NIMH) R01MH128199HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31NS12410HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31NS130979HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) FNS120640AHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS95809HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R35NS116879HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) T32NS099042HHS | NIH | National Institute on Drug Abuse (NIDA) F30DA048543HHS | NIH | National Institute on Drug Abuse (NIDA) R01DA35821NIDA NIH HHS F30 DA048543NIDA NIH HHS R01 DA035821NIMH NIH HHS R01 MH119154NIMH NIH HHS R01 MH123700NIMH NIH HHS R01 MH128199NINDS NIH HHS F31 NS130979NINDS NIH HHS F99 NS120640NINDS NIH HHS R01 NS095809NINDS NIH HHS R35 NS116879NINDS NIH HHS T32 NS099042
Abstract
Activity-dependent protein synthesis is crucial for long-lasting forms of synaptic plasticity. However, our understanding of translational mechanisms controlling GABAergic synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP) enhances postsynaptic clusters of GABA
Indexed as
Carrier ProteinsMembrane ProteinsMicroRNAsNeuronal PlasticityProtein BiosynthesisAnimalsCalcineurinGene Expression RegulationHistone DeacetylasesLong-Term PotentiationMiceNFATC Transcription FactorsReceptors, GABA-ARNA, MessengerSynapsesCalcineurinCarrier ProteinsgephyrinHistone DeacetylasesMembrane ProteinsMicroRNAsNFATC Transcription FactorsReceptors, GABA-ARNA, MessengerGABAA ReceptorGephyrinInhibitory SynapsemiRNATranslation
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.