Evidence map›Paper›PMID 39297167›Full record

ArticleiScience2024

Unveiling differential gene co-expression networks and its effects on levodopa-induced dyskinesia.

Tatiane Piedade de Souza, Gilderlanio Santana de Araújo, Leandro Magalhães, Giovanna C Cavalcante, Arthur Ribeiro-Dos-Santos, Camille Sena-Dos-Santos, Caio Santos Silva, Gracivane Lopes Eufraseo, Alana de Freitas Escudeiro, Giordano Bruno Soares-Souza and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatiane Piedade de SouzaLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Gilderlanio Santana de AraújoLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Leandro MagalhãesInstituto Tecnológico Vale, Belém 66055-090, Pará, Brazil.
Giovanna C CavalcanteLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Arthur Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Camille Sena-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Caio Santos SilvaLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Gracivane Lopes EufraseoLaboratório de Neurologia Experimental, Universidade Federal do Pará, Belém 66073-000, Pará, Brazil.
Alana de Freitas EscudeiroLaboratório de Neurologia Experimental, Universidade Federal do Pará, Belém 66073-000, Pará, Brazil.
Giordano Bruno Soares-SouzaLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
Bruno Lopes Santos-LobatoLaboratório de Neurologia Experimental, Universidade Federal do Pará, Belém 66073-000, Pará, Brazil.
Ândrea Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levodopa-induced dyskinesia (LID) refers to involuntary motor movements of chronic use of levodopa in Parkinson's disease (PD) that negatively impact the overall well-being of people with this disease. The molecular mechanisms involved in LID were investigated through whole-blood transcriptomic analysis for differential gene expression and identification of new co-expression and differential co-expression networks. We found six differentially expressed genes in patients with LID, and 13 in patients without LID. We also identified 12 co-expressed genes exclusive to LID, and six exclusive hub genes involved in 23 gene-gene interactions in patients with LID. Convergently, we identified novel genes associated with PD and LID that play roles in mitochondrial dysfunction, dysregulation of lipid metabolism, and neuroinflammation. We observed significant changes in disease progression, consistent with previous findings of maladaptive plastic changes in the basal ganglia leading to the development of LID, including a chronic pro-inflammatory state in the brain.

Indexed as

Clinical geneticsClinical neuroscienceMolecular neuroscience

Identifiers

PMID39297167
PMCPMC11409023

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.