Evidence map›Paper›PMID 39297974›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2025

Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?

Julian Eder, Martin Kräter, Clemens Kirschbaum, Wei Gao, Magdalena Wekenborg, Marlene Penz, Nicole Rothe, Jochen Guck, Lucas Daniel Wittwer, Andreas Walther

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julian EderBiopsychology, Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0009-0006-0610-1816
Martin KräterCenter for Molecular and Cellular Bioengineering, Biotechnology Center, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0001-7122-7331
Clemens KirschbaumBiopsychology, Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany.
Wei GaoBiopsychology, Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0001-9380-5366
Magdalena WekenborgBiopsychology, Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0002-4498-107X
Marlene PenzInstitute of Psychology, Johannes Kepler Universität Linz, Linz, Austria.ORCID https://orcid.org/0000-0003-0356-1594
Nicole RotheBiopsychology, Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany.
Jochen GuckCenter for Molecular and Cellular Bioengineering, Biotechnology Center, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0002-1453-6119
Lucas Daniel WittwerMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.ORCID https://orcid.org/0000-0002-8892-0025
Andreas WaltherClinical Psychology and Psychotherapy, University of Zurich, Binzmühlestrasse 14, Zurich, 8050, Switzerland. a.walther@psychologie.uzh.ch.ORCID http://orcid.org/0000-0003-4516-1783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell deformability of all major blood cell types is increased in depressive disorders (DD). Furthermore, impaired glucocorticoid secretion is associated with DD, as well as depressive symptoms in general and known to alter cell mechanical properties. Nevertheless, there are no longitudinal studies examining accumulated glucocorticoid output and depressive symptoms regarding cell deformability. The aim of the present study was to investigate, whether depressive symptoms predict cell deformability one year later and whether accumulated hair glucocorticoids mediate this relationship. In 136 individuals (n

Indexed as

CortisoneDepressionGlucocorticoidsHydrocortisoneMonocytesAdultAgedFemaleHairHumansLongitudinal StudiesMaleMiddle AgedYoung AdultCortisoneGlucocorticoidsHydrocortisoneCell deformabilityDepressive symptomsHair cortisolHair cortisoneReal-time deformability cytometry

Identifiers

PMID39297974
PMCPMC12148981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.