Evidence map›Paper›PMID 39300174›Full record

ArticleScientific reports2024

The role of 2'-5'-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice.

Mwense Leya, Daram Yang, Tien Huyen Ton Nu Bao, Hyuneui Jeong, Sang-Ik Oh, Jong-Hoon Kim, Jong-Won Kim, Bumseok Kim

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mwense Leya *Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Daram Yang *Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Tien Huyen Ton Nu Bao *Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Hyuneui JeongBiosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Sang-Ik OhBiosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Jong-Hoon KimBiosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Jong-Won KimBiosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea. jok148@pitt.edu.
Bumseok KimBiosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, 79, Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea. bskims@jbnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following an injury, the liver embarks on a process that drives the accumulation and reformation of the extracellular matrix, leading to hepatic fibrosis. Type I interferons (IFNs), including IFN-α and IFN-β, play a crucial role in averting chronic liver injury through the activation of IFN-stimulated genes (ISGs), which are instrumental in sculpting adaptive immunity. The role of 2'-5'-oligoadenylate synthase-like protein 1 (OASL1), an antiviral ISG, in the context of liver fibrosis remains to be elucidated. To elicit liver fibrosis, a diet containing 0.1% diethoxycarbonyl-1,4-dihydrocollidine (DDC) and carbon tetrachloride (CCl

Indexed as

2',5'-Oligoadenylate SynthetaseCarbon TetrachlorideAnimalsChemical and Drug Induced Liver InjuryDisease Models, AnimalLiverLiver CirrhosisMaleMiceMice, Inbred C57BLMice, KnockoutNF-kappa BPyridinesSignal Transduction2',5'-Oligoadenylate Synthetase3,5-diethoxycarbonyl-1,4-dihydrocollidineCarbon TetrachlorideNF-kappa BOasl1 protein, mousePyridinesLiver fibrosisMiceOASL1Type 1 IFN

Identifiers

PMID39300174
PMCPMC11413013

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.