Evidence mapPaperPMID 39300208Full record

ArticleNPJ digital medicine2024

Zero shot health trajectory prediction using transformer.

Pawel Renc, Yugang Jia, Anthony E Samir, Jaroslaw Was, Quanzheng Li, David W Bates, Arkadiusz Sitek

Abstract read
In one paragraph

Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
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  5. From Integrated Care to Learning Systems.Healthcare (Basel, Switzerland) · 2026
    Review
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  8. Article
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  12. Review
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  18. Article
  19. Differential dementia detection from multimodal brain images in a real-world dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pawel RencMassachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0487-7454
Yugang JiaMassachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0008-0628-5461
Anthony E SamirMassachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7801-8724
Jaroslaw WasAGH University of Krakow, Kraków, Poland.
Quanzheng LiMassachusetts General Hospital, Boston, MA, USA.
David W BatesHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6268-1540
Arkadiusz SitekMassachusetts General Hospital, Boston, MA, USA. sarkadiu@gmail.com.ORCID http://orcid.org/0000-0002-0677-4002

Funding

Deep learning Based Phenotyping and Treatment Optimization for Heart Failure with Preserved Ejection FractionR01HL159183 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LI, QUANZHENG · 2022 to 2025
$2.3M
NHLBI NIH HHS R01 HL159183U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) HL159183
6 · The paper itself

Abstract

Integrating modern machine learning and clinical decision-making has great promise for mitigating healthcare's increasing cost and complexity. We introduce the Enhanced Transformer for Health Outcome Simulation (ETHOS), a novel application of the transformer deep-learning architecture for analyzing high-dimensional, heterogeneous, and episodic health data. ETHOS is trained using Patient Health Timelines (PHTs)-detailed, tokenized records of health events-to predict future health trajectories, leveraging a zero-shot learning approach. ETHOS represents a significant advancement in foundation model development for healthcare analytics, eliminating the need for labeled data and model fine-tuning. Its ability to simulate various treatment pathways and consider patient-specific factors positions ETHOS as a tool for care optimization and addressing biases in healthcare delivery. Future developments will expand ETHOS' capabilities to incorporate a wider range of data types and data sources. Our work demonstrates a pathway toward accelerated AI development and deployment in healthcare.

Identifiers

PMID39300208
PMCPMC11412988

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.