Evidence map›Paper›PMID 39300329›Full record

ArticleBMC genomics2024

Genetic and genomic analysis of reproduction traits in holstein cattle using SNP chip data and imputed sequence level genotypes.

Leopold Schwarz, Ana-Marija Križanac, Helen Schneider, Clemens Falker-Gieske, Johannes Heise, Zengting Liu, Jörn Bennewitz, Georg Thaller, Jens Tetens

Abstract read
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Development and Application of a 40 K Liquid Capture Chip for Beef Cattle.Animals : an open access journal from MDPI · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leopold SchwarzDepartment of Animal Sciences, Georg-August-University, 37077, Göttingen, Germany. leopold.schwarz@uni-goettingen.de.ORCID http://orcid.org/0009-0008-0069-5320
Ana-Marija KrižanacDepartment of Animal Sciences, Georg-August-University, 37077, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7446-8031
Helen SchneiderInstitute of Animal Science, University of Hohenheim, 70599, Stuttgart, Germany.ORCID http://orcid.org/0000-0001-6272-5937
Clemens Falker-GieskeDepartment of Animal Sciences, Georg-August-University, 37077, Göttingen, Germany.ORCID http://orcid.org/0000-0001-9160-1909
Johannes HeiseVereinigte Informationssysteme Tierhaltung w.V. (VIT), 27283, Verden, Germany.ORCID http://orcid.org/0000-0002-7605-7148
Zengting LiuVereinigte Informationssysteme Tierhaltung w.V. (VIT), 27283, Verden, Germany.ORCID http://orcid.org/0000-0002-7112-0320
Jörn BennewitzInstitute of Animal Science, University of Hohenheim, 70599, Stuttgart, Germany.ORCID http://orcid.org/0000-0001-6450-1160
Georg ThallerInstitute of Animal Breeding and Husbandry, Christian-Albrechts-University, 24118, Kiel, Germany.ORCID http://orcid.org/0000-0002-6782-2039
Jens TetensDepartment of Animal Sciences, Georg-August-University, 37077, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5352-464X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReproductive performance plays an important role in animal welfare, health and profitability in animal husbandry and breeding. It is well established that there is a negative correlation between performance and reproduction in dairy cattle. This relationship is being increasingly considered in breeding programs. By elucidating the genetic architecture of underlying reproduction traits, it will be possible to make a more detailed contribution to this. Our study followed two approaches to elucidate this area; in a first part, variance components were estimated for 14 different calving and fertility traits, and then genome-wide association studies were performed for 13 reproduction traits on imputed sequence-level genotypes with subsequent enrichment analyses.

resultsVariance components analyses showed a low to moderate heritability (h

conclusionOur results confirm previous findings of other authors in a comprehensive cohort including 13 different traits at the same time. Additionally, we identified new candidate genes involved in dairy cattle reproduction and made initial suggestions regarding their potential impact, with special regard to the X chromosome as a putative information source for further research. This work can make a contribution to reveal the genetic architecture of reproduction traits in context of trait specific interactions.

Indexed as

Genome-Wide Association StudyGenotypePolymorphism, Single NucleotideReproductionAnimalsCattleFemaleFertilityGenomicsPhenotypeQuantitative Trait, HeritableQuantitative Trait Loci

Identifiers

PMID39300329
PMCPMC11411901

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.