Evidence map›Paper›PMID 39301218›Full record

ArticleFrontiers in cellular neuroscience2024

Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent.

Chandrakumar Bogguri, Vivek Kurien George, Beheshta Amiri, Alexander Ladd, Nicholas R Hum, Aimy Sebastian, Heather A Enright, Carlos A Valdez, T Nathan Mundhenk, Jose Cadena and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chandrakumar BogguriPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Vivek Kurien GeorgeEngineering Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Beheshta AmiriPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Alexander LaddEngineering Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Nicholas R HumPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Aimy SebastianPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Heather A EnrightPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Carlos A ValdezGlobal Security Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
T Nathan MundhenkEngineering Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Jose CadenaEngineering Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Doris LamPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that can manifest into chronic neurological illnesses later in life. There is still a large need for technological advancement to better understand changes in brain function following OPNA exposure. The human-relevant

Indexed as

acute exposurehuman induced pluripotent stem cellshuman neuronal activitymicrophysiological systemsmulti-electrode arraynerve agentorganophosphate

Identifiers

PMID39301218
PMCPMC11410629

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.