Evidence mapPaperPMID 39301299Full record

ReviewJGH open : an open access journal of gastroenterology and hepatology2024

Efficacy of albumin use in decompensated cirrhosis and real-world adoption in Australia.

Eric Kalo, Scott Read, Asma Baig, Kate Marshall, Wai-See Ma, Helen Crowther, Cameron Gofton, Kate D Lynch, Siddharth Sood, Jacinta Holmes and 7 more

Abstract readReview
In one paragraph

Review in JGH open : an open access journal of gastroenterology and hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eric KaloBlacktown Clinical School and Research Centre, School of Medicine Western Sydney University Blacktown New South Wales Australia.ORCID https://orcid.org/0000-0002-6770-3857
Scott ReadBlacktown Clinical School and Research Centre, School of Medicine Western Sydney University Blacktown New South Wales Australia.
Asma BaigBlacktown Hospital, Western Sydney Local Health District Blacktown New South Wales Australia.
Kate MarshallRoyal Prince Alfred Hospital Sydney New South Wales Australia.
Wai-See MaBlacktown Hospital, Western Sydney Local Health District Blacktown New South Wales Australia.
Helen CrowtherBlacktown Hospital, Western Sydney Local Health District Blacktown New South Wales Australia.
Cameron GoftonStorr Liver Centre, The Westmead Institute for Medical Research University of Sydney Westmead New South Wales Australia.
Kate D LynchDepartment of Gastroenterology and Hepatology Royal Adelaide Hospital, Central Adelaide Local Health Network Adelaide South Australia Australia.
Siddharth SoodDepartment of Gastroenterology Northern Health Melbourne Victoria Australia.
Jacinta HolmesDepartment of Medicine The University of Melbourne Parkville Victoria Australia.
John LubelDepartment of Gastroenterology Alfred Health Melbourne Victoria Australia.
Alan WiggHepatology and Liver Transplant Medicine Unit Southern Adelaide Local Health Network Adelaide South Australia Australia.
Geoff McCaughanA.W. Morrow Gastroenterology and Liver Centre Centenary Research Institute for Cancer Research and Cell Biology Camperdown New South Wales Australia.
Stuart K RobertsDepartment of Gastroenterology Alfred Health Melbourne Victoria Australia.
Paolo CaraceniUnit of Semeiotics, Liver and Alcohol-Related Diseases IRCCS Azienda-Ospedaliera Universitaria di Bologna, EMR Bologna Italy.
Golo AhlenstielBlacktown Clinical School and Research Centre, School of Medicine Western Sydney University Blacktown New South Wales Australia.
Avik MajumdarDepartment of Medicine The University of Melbourne Parkville Victoria Australia.ORCID https://orcid.org/0000-0003-2975-4327

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current treatment approach to patients with liver cirrhosis relies on the individual management of complications. Consequently, there is an unmet need for an overall therapeutic strategy for primary and secondary prevention of complications. The clinical potential of long-term albumin infusions supported by recent clinical trials has expanded its indications and holds promise to transform the management and secondary prevention of cirrhosis-related complications. This renewed interest in albumin comes with inherent controversies, compounding challenges and pressing need for rigorous evaluation of its clinical potential to capitalize on its therapeutic breakthroughs. Australia is among a few countries worldwide to adopt outpatient human albumin infusion. Here, we summarize currently available evidence of the potential benefits of human albumin for the management of multiple liver cirrhosis-related complications and discuss key challenges for wide application of long-term albumin administration strategy in Australian clinical practice. Australian Gastroenterological week (AGW), organised by the Gastroenterological Society of Australia (GESA), was held between 9-11 September 2022. A panel of hepatologists, advanced liver nurses and one haematologist, were invited to a roundtable meeting to discuss the use of long-term albumin infusions for liver cirrhosis. management in Australia. In this review, we summarise the proceedings of this meeting in context of the current literature.

Indexed as

albuminchallengescirrhosiscomplicationsdecompensationevidenceinfusionslong‐term

Identifiers

PMID39301299
PMCPMC11410680

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.