Evidence map›Paper›PMID 39301397›Full record

ReviewCureus2024

Laryngopharyngeal Reflux Pathophysiology, Clinical Presentation, and Management: A Narrative Review.

William T Barham, Alana V Alvarez-Amado, Kathryn M Dillman, Elise Thibodeaux, Ivan D Nguyen, Giustino Varrassi, Catherine J Armstrong, Jeffrey Howard, Shahab Ahmadzadeh, Chizoba N Mosieri and 3 more

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Psychosocial Interventions in Laryngopharyngeal Reflux: An Institutional Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

William T BarhamSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Alana V Alvarez-AmadoSchool of Medicine, American University of the Caribbean, Cupecoy, SXM.
Kathryn M DillmanSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Elise ThibodeauxSchool of Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.
Ivan D NguyenSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Giustino VarrassiPain Medicine, Paolo Procacci Foundation, Rome, ITA.
Catherine J ArmstrongDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Jeffrey HowardDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Shahab AhmadzadehDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Chizoba N MosieriDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Adam M KayeDepartment of Pharmacy Practice, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laryngopharyngeal reflux (LPR) is a common and often misinterpreted clinical entity responsible for various symptoms affecting the upper aerodigestive tract. This narrative literature review aims to review the pathophysiology, symptoms, and management of LPR, emphasizing the emerging understanding of gastric content reflux in aerodigestive tissue irritation. Understanding the pathophysiology of LPR will allow general practitioners and specialists to accurately recognize and treat a condition that causes substantial morbidity in the affected patients. Using evidence-based findings from randomized controlled trials, clinical studies, and meta-analyses, the present investigation aims to outline and unify previous research into LPR. A review of anatomical structures, pathogenic mechanisms, endoscopic findings in LPR, and clinical manifestations and treatment options are also discussed. Though controversy around the diagnosis and management of LPR persists, emerging research in cellular damage and diagnostic tools promises to provide increasingly accurate and reliable modalities for characterizing LPR. Hopefully, future research will unify the field and provide overarching guidelines for both primary care and specialists. The present investigation provides an integrated perspective on LPR, a clinically prevalent and complex disease.

Indexed as

asthmabile acidschronic coughgerdlaryngopharyngeal refluxpepsin

Identifiers

PMID39301397
PMCPMC11412619

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.