Evidence map›Paper›PMID 39302339›Full record

ArticleeLife2024

Dynamic chromatin architecture identifies new autoimmune-associated enhancers for

Matthew C Pahl, Prabhat Sharma, Rajan M Thomas, Zachary Thompson, Zachary Mount, James A Pippin, Peter A Morawski, Peng Sun, Chun Su, Daniel Campbell and 2 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. AmalgaMo: flexible DNA motif merging.Bioinformatics advances · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew C Pahl *Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0002-4720-1921
Prabhat Sharma *Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Rajan M Thomas *Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Zachary ThompsonCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Zachary MountCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
James A PippinCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Peter A MorawskiBenaroya Research Institute at Virginia Mason, Seattle, United States.
Peng SunCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Chun SuCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.
Daniel CampbellBenaroya Research Institute at Virginia Mason, Seattle, United States.
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0003-2025-5302
Andrew D WellsCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0002-3630-2145

Funding

Functional Mechanisms of T1D Risk Variants and their Target Genes using 3D Epigenomics and Single Cell ApproachesR01DK122586 · NIDDK · UNIVERSITY OF VIRGINIA · PI GRANT, STRUAN F A, RICH, STEPHEN S. · 2019 to 2022
$4.8M
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune toleranceR01AI154773 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI CAMPBELL, DANIEL J, WELLS, ANDREW D · 2021 to 2025
$3.8M
Regulation of cutaneous immunity and tissue-repair by a specialized population of CD4+ T cellsR01AI127726 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J, GRATZ, IRIS KARINA · 2017 to 2021
$2.8M
Intergenic cis regulatory elements in the control of IL-2 and IL-21R21AI110179 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WELLS, ANDREW D · 2014 to 2015
$462k
NIAID NIH HHS R01 AI127726NIAID NIH HHS R01 AI154773NIAID NIH HHS R21 AI110179NIDDK NIH HHS R01 DK122586NIH HHS R01AI137143NIH HHS R01DK122586NIH HHS R21AI110179
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are located in non-coding regions and likely impact

Indexed as

CD4-Positive T-LymphocytesChromatinGenome-Wide Association StudyInterleukin-2Lymphocyte ActivationAnimalsAutoimmune DiseasesAutoimmunityEnhancer Elements, GeneticGene Expression RegulationHumansMiceChromatinIL2 protein, humanInterleukin-2chromosomesepigeneticsgene expressiongene regulationgeneticshumanimmunologyinflammationmouse

Identifiers

PMID39302339
PMCPMC11418197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.