Evidence map›Paper›PMID 39304470›Full record

ArticleBritish journal of anaesthesia2024

Propofol binds and inhibits skeletal muscle ryanodine receptor 1.

Thomas T Joseph, Weiming Bu, Omid Haji-Ghassemi, Yu S Chen, Kellie Woll, Paul D Allen, Grace Brannigan, Filip van Petegem, Roderic G Eckenhoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Thomas T JosephDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: thomas.joseph@pennmedicine.upenn.edu.
Weiming BuDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Omid Haji-GhassemiDepartment of Biochemistry, University of British Columbia, Vancouver, BC, Canada.
Yu S ChenDepartment of Biochemistry, University of British Columbia, Vancouver, BC, Canada.
Kellie WollDepartment of Biochemistry, University of British Columbia, Vancouver, BC, Canada.
Paul D AllenDepartment of Anesthesiology, University of Tennessee, Knoxville, TN, USA.
Grace BranniganDepartment of Physics and Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA.
Filip van PetegemDepartment of Biochemistry, University of British Columbia, Vancouver, BC, Canada.
Roderic G EckenhoffDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Mechanisms of RyR1 Modulation by General AnestheticsR01GM135633 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ECKENHOFF, RODERIC G, VAN PETEGEM, FILIP · 2020 to 2023
$1.7M
Efficient prediction of transmembrane binding sites for anesthetic ligandsK08GM139031 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH, THOMAS THENGANPALLIL · 2020 to 2024
$984k
NIGMS NIH HHS K08 GM139031NIGMS NIH HHS R01 GM135633
6 · The paper itself

Abstract

backgroundAs the primary Ca

methodsRyR1 opening was measured by [

resultsBoth propofol and AziPm decreased RyR1 opening in planar lipid bilayers (P<0.01) and heavy SR vesicles, and inhibited activator-induced Ca

conclusionsPropofol demonstrated direct binding and inhibition of RyR1 at clinically plausible concentrations, consistent with the hypothesis that propofol partially mitigates malignant hyperthermia by inhibition of induced Ca

Indexed as

Anesthetics, IntravenousMuscle, SkeletalPropofolRyanodine Receptor Calcium Release ChannelBinding SitesCalciumHumansMalignant HyperthermiaMolecular Dynamics SimulationMuscle Fibers, SkeletalSarcoplasmic ReticulumAnesthetics, IntravenousCalciumPropofolRyanodine Receptor Calcium Release ChannelRYR1 protein, humanfree energy perturbationmalignant hyperthermiaphotoaffinity labellingpropofolryanodine receptor 1skeletal muscle

Identifiers

PMID39304470
PMCPMC11488158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.