Evidence map›Paper›PMID 39305302›Full record

ArticleArchives of dermatological research2024

ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells.

Haiyan Li, Zedong Chen, Yuanjie Huang, Chen Chen, Limin Cai

Abstract read
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In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haiyan LiDepartment of Dermatology, Harbin Medical University Cancer Hospital, Harbin, 150081, Heilongjiang, P.R. China.
Zedong ChenDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China.
Yuanjie HuangDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China.
Chen ChenDepartment of Dermatology, The Second Hospital of Harbin, Harbin, 150056, Heilongjiang, P.R. China.
Limin CaiDepartment of Dermatology, The First Affiliated Hospital of Harbin Medical University, No. 199, Dazhi Street, Nangang District, Harbin, 150001, Heilongjiang, P.R. China. jeremy145@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis, a key factor in tumor progression, is poorly understood at the molecular level. This study investigates how ELK4 and CHMP6 regulate skin cutaneous melanoma (SKCM) cell proliferation and ferroptosis. Analysis of TCGA data reveals high expression of ELK4 and CHMP6 in SKCM. Overexpression of ELK4 or CHMP6 enhances cell proliferation, invasion, and migration while reducing ROS and Fe2 + levels. It also increases GPX4 and xCT expression and decreases ACSL4 levels in SKCM cells. The opposite effects are observed with ELK4 or CHMP6 knockdown. ELK4 binds to the CHMP6 promoter, promoting CHMP6 transcription. Knockdown of CHMP6 reverses the oncogenic effects of ELK4 overexpression. In conclusion, ELK4 enhances proliferation, invasion, and migration while inhibiting ferroptosis in SKCM cells by upregulating CHMP6 transcription. This study sheds light on the intricate mechanisms involved in SKCM progression and identifies potential therapeutic targets in melanoma treatment.

Indexed as

Cell MovementCell ProliferationFerroptosisGene Expression Regulation, NeoplasticMelanomaSkin NeoplasmsAmino Acid Transport System y+Cell Line, TumorCoenzyme A LigasesCutaneous Malignant MelanomaEndosomal Sorting Complexes Required for Transportets-Domain Protein Elk-4HumansLong-Chain-Fatty-Acid-CoA LigaseNeoplasm InvasivenessPhospholipid Hydroperoxide Glutathione PeroxidaseAmino Acid Transport System y+CHMP6 protein, humanCoenzyme A LigasesELK4 protein, humanEndosomal Sorting Complexes Required for Transportets-Domain Protein Elk-4Long-Chain-Fatty-Acid-CoA LigasePhospholipid Hydroperoxide Glutathione PeroxidaseSLC7A11 protein, humanCHMP6ELK4FerroptosisSkin cutaneous melanomaTranscription

Identifiers

PMID39305302

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.