Evidence mapPaperPMID 39305330Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review.

Shirin Zahra Farhad, Amirreza Karbalaeihasanesfahani, Esmaeel Dadgar, Kamyar Nasiri, Narges Mohammad Hosseini, Neda Valian, Mahla Esfahaniani, Mohsen Nabi Afjadi

Abstract readReview
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In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shirin Zahra FarhadDepartment of Periodontics, Faculty of Dentistry, Isfahan(Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Amirreza KarbalaeihasanesfahaniFaculty of Dentistry, Semmelweis University, Budapest, Hungary.
Esmaeel DadgarFaculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Kamyar NasiriFaculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran.
Narges Mohammad HosseiniFaculty of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Neda ValianFaculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Mahla EsfahanianiFaculty of Dentistry, Golestan University of Medical Sciences, Gorgan, Iran. Mahlaesfahaniani@gmail.com.
Mohsen Nabi AfjadiDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. mohsen.nabiafjadi@modares.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol (RV-3, 5, 4'-trihydroxystilbene) is a natural compound found in plants like red grapes, berries, and peanuts, with promising effects on dental health. It helps strengthen tooth enamel by promoting remineralization, making the teeth more resistant to decay caused by acid-producing bacteria. RV also shields dentin, a vulnerable layer beneath the enamel, from erosion and sensitivity. Its anti-inflammatory properties can reduce inflammation associated with dental conditions such as pulpitis and endodontic diseases. Moreover, RV's antimicrobial activity inhibits the growth of bacteria involved in dental plaque and biofilm formation, preventing their accumulation on the tooth surface. This contributes to a healthier oral environment and prolongs the lifespan of dental restorative materials. However, the research on RV's impact on dental health is in its early stages, and further studies are needed to confirm potential benefits. Important factors such as determining the optimal dosage, understanding its bioavailability, and assessing potential side effects require further investigation. This review focuses on the important role of RV in promoting dental health. It delves into various aspects, including its impact on root health, maintenance of the dental pulp, care for tooth enamel, effectiveness of dental restorative materials, and health of dentin.

Indexed as

Oral HealthResveratrolAnimalsAnti-Inflammatory AgentsHumansAnti-Inflammatory AgentsResveratrolAntimicrobial propertiesDental healthDentinRemineralizationResveratrol

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.