Evidence map›Paper›PMID 39305437›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2024

Exploration of the association between new "Life's Essential 8" with hyperuricemia and gout among US adults.

Yingdong Han, Hong Di, Yibo Wang, Jiayi Yi, Yu Cao, Xinxin Han, Shuolin Wang, He Zhao, Yun Zhang, Xuejun Zeng

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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingdong Han *State Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Hong Di *State Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Yibo WangState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Jiayi YiDepartment of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China.
Yu CaoState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Xinxin HanState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Shuolin WangState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
He ZhaoState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China.
Yun ZhangState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China. zhangyun10806@pumch.cn.ORCID http://orcid.org/0000-0002-6373-0647
Xuejun ZengState Key Laboratory of Complex Severe and Rare Diseases, Department of Family Medicine & Division of General Internal Medicine, Department of Internal Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Beijing, 100730, China. zxjpumch@126.com.

Funding

2019 Discipline Development Project of Peking Union Medical College 201920200106National High Level Hospital Clinical Research Funding 2022-PUMCH-B-044the National Natural Science Foundation of China 81901667the National Natural Science Foundation of China 82071841
6 · The paper itself

Abstract

backgroundPrevious researches have reported the relationship between uric acid and cardiovascular disease. We aimed to investigate the association of Life's Essential 8, a recently updated measurement of cardiovascular health, with the prevalence of hyperuricemia (HUA) and gout among US adults. Additionally, we also explored the relationship between LE8 and all-cause mortality among patients with HUA or gout.

methodsParticipants from the National Health and Nutrition Examination Survey in 2007-2016 were involved in this study. LE8 score was categorized into low, moderate, high CVH groups according to American Heart Association definitions. Multivariable logistic regression and cox regression analyses, restricted cubic spline models, subgroup analysis and sensitivity analysis were used to explore the associations.

resultsA total of 23,619 adult participants were included in this study, which included 4,775 hyperuricemia patients and 1,055 gout patients. Among all participants, the overall median LE8 score was 65.62 (21.25) and the prevalence of hyperuricemia and gout of were 20.2% and 4.5%, respectively. After fully adjusted the potential confounders, participants in high CVH group had a lower prevalence of hyperuricemia and gout compared with the low CVH group, with a OR (95%CI) of 0.50 (0.39-0.63) and 0.50 (0.30-0.82), respectively. The restricted cubic spline showed a significantly inverse relationship between LE8 and hyperuricemia and gout. Similar patterns were also identified in the association between LE8 scores and all-cause mortality in HUA and gout patients.

conclusionsHigher LE8 scores are associated with lower risk and lower all-cause mortality of HUA and gout among US adults. Adherence to optimal CVH metrics may be an appropriate prevention and management strategy for reducing the socioeconomic burden of hyperuricemia and gout.

Indexed as

GoutHyperuricemiaNutrition SurveysAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeUnited StatesCardiovascular healthGoutLife’s essential 8NHANESUric acid

Identifiers

PMID39305437
PMCPMC11599414

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.