ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025
Longitudinal gut microbiota composition during the perinatal period in women with different intensities of depressive symptoms.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The microbiota-gut-brain axis in postpartum depression: a review of microbial mechanisms and therapeutic potential.Frontiers in psychiatry · 2026Review
- The microbiota-gut-brain axis in depression: unraveling the relationships and therapeutic opportunities.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveDepressive symptoms during the perinatal period significantly impact mothers and infants. Emerging evidence suggests a connection between gut microbiota and mood regulation. This study investigated whether depressive symptoms are associated with changes in the gut microbiota of women during the perinatal period.
methodsThirty-four pregnant women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS) and categorized based on symptom severity. Stool samples were collected during the third trimester and at two postpartum timepoints. All samples underwent 16S rRNA gene sequencing and quantification of short-chain fatty acids (SCFA) by gas chromatography-mass spectrometry (GC-MS).
resultsNo differences in SCFA concentrations were observed between groups (p > 0.05). However, postpartum women with moderate to severe symptoms (MS group) had a significant increase in Enterobacteriaceae abundance compared to women with mild or absent symptoms (AM group) (p < 0.05). The Bifidobacterium genus increased significantly in both groups over time (p < 0.05). The MS group showed a reduction in depressive symptoms during psychiatric treatment (p < 0.05).
conclusionThese findings suggest a link between gut microbiota and perinatal depressive symptoms. Further research using microbiome-targeted approaches is needed to understand the broader implications for maternal health.
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