Evidence map›Paper›PMID 39306249›Full record

ReviewAgeing research reviews2024

Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition.

Wei-En Wang, Breton M Asken, Jesse C DeSimone, Shellie-Anne Levy, Warren Barker, Jacob A Fiala, Idaly Velez-Uribe, Rosie E Curiel Cid, Monica Rósselli, Michael Marsiske and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ancestry-specific effects ofmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wei-En Wang1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Breton M Asken1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Jesse C DeSimone1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Shellie-Anne Levy1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Warren Barker1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami, FL, USA.
Jacob A Fiala1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Idaly Velez-Uribe1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami, FL, USA.
Rosie E Curiel Cid1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Departments of Psychiatry and Behavioral Sciences and Neurology, Center for Cognitive Neuroscience and Aging, University of Miami, Miami, FL, USA.
Monica Rósselli1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Psychology, Florida Atlantic University, Davie, FL, USA.
Michael Marsiske1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Malek Adjouadi1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, Florida International University, Miami, FL, USA.
David A Loewenstein1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Departments of Psychiatry and Behavioral Sciences and Neurology, Center for Cognitive Neuroscience and Aging, University of Miami, Miami, FL, USA.
Ranjan Duara1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami, FL, USA.
Glenn E Smith1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Melissa J Armstrong1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Neurology, Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
David E Vaillancourt1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology, Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Stephen A Coombes1Florida Alzheimer's Disease Research Center (ADRC), University of Florida, Gainesville, FL, USA; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA. Electronic address: scoombes@ufl.edu.

Funding

Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6M
MRI markers of brain aging and risk factors for cognitive decline in older African AmericansR01AG056405 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2018 to 2023
$3.6M
Prospective study of bilingualism and cognitive reserve in the aging brain of Hispano adults with MCIR01AG080468 · NIA · FLORIDA ATLANTIC UNIVERSITY · PI Stephen Coombes, MONICA ROSSELLI · 2023 to 2026
$2.7M
NIA NIH HHS P30 AG066506NIA NIH HHS R01 AG056405NIA NIH HHS R01 AG080468
6 · The paper itself

Abstract

Neuroimaging and biofluid biomarkers provide a proxy of pathological changes for Alzheimer's disease (AD) and are useful in improving diagnosis and assessing disease progression. However, it is not clear how race/ethnicity and different prevalence of AD risks impact biomarker levels. In this narrative review, we survey studies focusing on comparing biomarker differences between non-Hispanic White American(s) (NHW), African American(s) (AA), Hispanic/Latino American(s) (HLA), and Asian American(s) with normal cognition, mild cognitive impairment, and dementia. We found no strong evidence of racial and ethnic differences in imaging biomarkers after controlling for cognitive status and cardiovascular risks. For biofluid biomarkers, in AA, higher levels of plasma Aβ42/Aβ40, and lower levels of CSF total tau and p-tau 181, were observed after controlling for APOE status and comorbidities compared to NHW. Examining the impact of AD risks and comorbidities on biomarkers and their contributions to racial/ethnic differences in cognitive impairment are critical to interpreting biomarkers, understanding their generalizability, and eliminating racial/ethnic health disparities.

Indexed as

BiomarkersNeuroimagingAgedAlzheimer DiseaseCognitionCognitive DysfunctionEthnicityHumansRacial GroupsBiomarkersAlzheimer’s diseaseBiomarkersEthnicityFluid biomarkersMagnetic resonance imagingNeuroimagingPositron emission tomographyRace

Identifiers

PMID39306249
PMCPMC11531386

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.