Evidence map›Paper›PMID 39307006›Full record

ArticleJournal of the neurological sciences2024

Psychiatric predictors of quality of life in Parkinson's disease: A three-year longitudinal study.

W Alex Dalrymple, Sara K Trach, Joseph L Flanigan, James T Patrie, Katharine Henry, Madaline B Harrison, Matthew J Barrett, Renzo Figari-Jordan, Binit B Shah, M Agustina Rossetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

W Alex DalrympleDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: wad5g@virginia.edu.
Sara K TrachDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: gps8gm@uvahealth.org.
Joseph L FlaniganDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: jlf4m@virginia.edu.
James T PatrieDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. Electronic address: jp4h@virginia.edu.
Katharine HenryDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: xps3pe@uvahealth.org.
Madaline B HarrisonDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: mbh3y@virginia.edu.
Matthew J BarrettDepartment of Neurology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: matthew.barrett@vcuhealth.org.
Renzo Figari-JordanDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: bmj5cn@virginia.edu.
Binit B ShahDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: bbs7s@virginia.edu.
M Agustina RossettiDepartment of Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address: say5ps@virginia.edu.

Funding

Clinical Research Site for the Network of Excellence in Neuroscience Clin. TrialsU10NS077260 · NINDS · UNIVERSITY OF VIRGINIA · PI QUIGG, MARK S · 2011 to 2017
$1.7M
Development and characterization of EEG signature of cognitive fluctuations in Lewy body dementiaR21AG077469 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BARRETT, MATTHEW JAMES, MUKHOPADHYAY, NITAI D. · 2022 to 2022
$427k
NIA NIH HHS R21 AG077469NINDS NIH HHS U10 NS077260
6 · The paper itself

Abstract

introductionParkinson's disease (PD) is associated with worsened quality of life (QOL) over time. Few longitudinal studies exist investigating the relationship of psychiatric comorbidities with QOL in people with PD (PwP). We sought to determine specific psychiatric symptoms associated with decreasing QOL in PwP over time.

methodsWe recruited PwP without dementia from a movement disorders clinic at an academic medical center. Participants were evaluated annually with motor and neuropsychological assessments at each visit. QOL was measured using the Parkinson's Disease Questionnaire-39 (PDQ-39). We assessed psychiatric symptoms, including depression (Beck Depression Inventory II, BDI-II), anxiety (Beck Anxiety Index, BAI), and apathy (Apathy Scale). Psychosis and impulse control disorders (ICDs) were recorded as present or absent. Using random coefficient regression, we analyzed psychiatric features associated with worsened QOL in PwP over three years.

resultsFrom the 105 participants enrolled at baseline, 67 completed three years of follow up. Mean PDQ-39 scores increased from 16.0 at baseline to 19.8 at year three. In multivariate analysis, higher BDI-II scores, BAI scores, and apathy scores were uniquely associated with worsened QOL over time (p < 0.001 for all measures), while presence of ICDs (p = 0.18) or psychosis (p = 0.10) were not. Changes in the BAI score and the BDI-II score exerted similar effects on the overall PDQ-39 score.

conclusionDepression, anxiety, and apathy are all associated with worsening quality of life over time in PwP, while presence of ICDs and psychosis are not. Treatment of these symptoms may lead to improved QOL in PwP.

Indexed as

Parkinson DiseaseQuality of LifeAgedAnxietyApathyDepressionFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersAnxietyDepressionMoodParkinson's diseaseQuality of life

Identifiers

PMID39307006
PMCPMC11563906

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.