Evidence map›Paper›PMID 39307344›Full record

ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2024

Barley based gluten free beer - A blessing or an uncontrollable risk?

Elena Cubero-Leon, Charlotte B Madsen, Katharina A Scherf, Michelle L Colgrave, Jørgen V Nørgaard, Minna Anthoni, Katerina Rizou, Michael J Walker, Ludvig M Sollid

Abstract readReview
In one paragraph

Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elena Cubero-LeonEuropean Commission, Joint Research Centre (JRC), Geel, Belgium. Electronic address: elena.cubero-leon@ec.europa.eu.
Charlotte B MadsenNational Food Institute, Technical University of Denmark, Lyngby, Denmark.
Katharina A ScherfLeibniz Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany; Technical University of Munich, TUM School of Life Sciences, Professorship of Food Biopolymer Systems, Freising, Germany.
Michelle L ColgraveCSIRO Agriculture and Food, 306 Carmody Rd, St Lucia, QLD, 4067, Australia.
Jørgen V NørgaardEuropean Commission, Joint Research Centre (JRC), Geel, Belgium.
Minna AnthoniFinnish Food Authority, Mustialankatu 3, 00790, Helsinki, Finland.
Katerina RizouGeneral Chemical State Laboratory (GCSL), Athens, Greece.
Michael J WalkerInstitute for Global Food Security, The Queen's University of Belfast, Belfast, BT9 5HN, Northern Ireland, UK.
Ludvig M SollidNorwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Norway and Department of Immunology, Oslo, University Hospital - Rikshospitalet, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent reports have highlighted that beer labelled "gluten-free", crafted with enzymatic treatments to remove gluten, may contain polypeptides that could be immunotoxic to individuals with coeliac disease. As strict adherence to a gluten-free diet is the only way to manage this condition, accurate labelling is crucial to those with coeliac disease. This paper aims to discuss the presence, levels and immunogenicity of gluten peptides found in gluten-reduced barley beers. While advances have been made in the detection and quantification of gluten peptides in beer, there are still challenges to the interpretation of gluten measurements as well as to assess whether peptides are immunotoxic in vivo. To make progress, future efforts should involve a combination of in vivo toxicity assessment of the degraded proteins, development of standardised gluten-free production strategies to minimise variability in gluten fragment presence, guidance on how to control the outcome as well as to develop appropriate reference materials and calibrators.

Indexed as

BeerCeliac DiseaseDiet, Gluten-FreeGlutensHordeumHumansGlutensCoeliac diseaseGluten-free beerGluten quantificationHydrolysisReference materialsRisk assessment

Identifiers

PMID39307344
PMCPMC11581983

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.