Evidence map›Paper›PMID 39307846›Full record

ReviewProgress in orthodontics2024

Integrated bioinformatic analysis of protein landscape in gingival crevicular fluid unveils sequential bioprocess in orthodontic tooth movement.

Yao Chen, Li Mei, Yuran Qian, Xinlianyi Zhou, Zhihe Zhao, Wei Zheng, Yu Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in orthodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao ChenState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Li MeiDiscipline of Orthodontics, Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, 9016, New Zealand.
Yuran QianState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xinlianyi ZhouState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Zhihe ZhaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Wei ZhengState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. Zhengwei81101@163.com.
Yu LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. yuli@scu.edu.cn.ORCID http://orcid.org/0000-0001-8578-7268

Funding

International Orthodontics Foundation 2022 Elite Research GrantNational Natural Science Foundation of China 31971247
6 · The paper itself

Abstract

backgroundThe biological mechanisms driving orthodontic tooth movement (OTM) remain incompletely understood. Gingival crevicular fluid (GCF) is an important indicator of the periodontal bioprocess, providing valuable cues for probing the molecular mechanisms of OTM.

methodsA rigorous review of the clinical studies over the past decade was conducted after registering the protocol with PROSPERO and adhering to inclusion criteria comprising human subjects, specified force magnitudes and force application modes. The thorough screening investigated differentially expressed proteins (DEPs) in GCF associated with OTM. Protein-protein interaction (PPI) analysis was carried out using the STRING database, followed by further refinement through Cytoscape to isolate top hub proteins.

resultsA comprehensive summarization of the OTM-related GCF studies was conducted, followed by an in-depth exploration of biomarkers within the GCF. We identified 13 DEPs, including ALP, IL-1β, IL-6, Leptin, MMP-1, MMP-3, MMP-8, MMP-9, PGE

conclusionsThis work has further improved our understanding to the bioprocess of OTM, suggesting biomarkers as potential modulating targets to enhance OTM, mitigate adverse effects and support real-time monitoring and personalized orthodontic cycles.

Indexed as

BiomarkersComputational BiologyGingival Crevicular FluidTooth Movement TechniquesDinoprostoneHumansInterleukin-6LeptinMatrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix Metalloproteinase 8Matrix Metalloproteinase 9OsteoprotegerinProtein Interaction MapsRANK LigandTransforming Growth Factor beta1BiomarkersDinoprostoneInterleukin-6LeptinMatrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix Metalloproteinase 8Matrix Metalloproteinase 9MMP3 protein, humanOsteoprotegerinRANK LigandTNFRSF11B protein, humanTNFSF11 protein, humanTransforming Growth Factor beta1Tumor Necrosis Factor-alphaBioinformatic analysisBiomarkerCytokineGingival crevicular fluidOrthodontic tooth movement

Identifiers

PMID39307846
PMCPMC11417088

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.