Evidence map›Paper›PMID 39307974›Full record

ArticleACS chemical neuroscience2024

Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome.

H T Evans, T Ko, M M Oliveira, A Yu, S V Kalavai, E N Golhan, A Polavarapu, E Balamoti, V Wu, E Klann and 1 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

H T EvansCenter for Neural Science, New York University, New York, New York 10003, United States.
T KoDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3070-9243
M M OliveiraCenter for Neural Science, New York University, New York, New York 10003, United States.
A YuCenter for Neural Science, New York University, New York, New York 10003, United States.ORCID 0009-0003-7255-4512
S V KalavaiCenter for Neural Science, New York University, New York, New York 10003, United States.
E N GolhanCenter for Neural Science, New York University, New York, New York 10003, United States.
A PolavarapuCenter for Neural Science, New York University, New York, New York 10003, United States.
E BalamotiCenter for Neural Science, New York University, New York, New York 10003, United States.ORCID 0009-0006-9573-9116
V WuCenter for Neural Science, New York University, New York, New York 10003, United States.
E KlannCenter for Neural Science, New York University, New York, New York 10003, United States.
D TraunerDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-6782-6056

Funding

Translational Control in Memory and Brain DisordersR35NS122316 · NINDS · NEW YORK UNIVERSITY · PI Eric Klann · 2021 to 2026
$6.5M
Optical control of neuromodulatory GPCRsRF1MH123246 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD, TRAUNER, DIRK HARTWIG · 2020 to 2020
$3.3M
Dysregulated Ribosomal Protein Synthesis in Amyloid and Tau Mouse ModelsR21NS121786 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2021 to 2021
$436k
NIMH NIH HHS RF1 MH123246NINDS NIH HHS R21 NS121786NINDS NIH HHS R35 NS122316
6 · The paper itself

Abstract

Elucidating the mechanisms by which protein synthesis contributes to complex biological processes has remained a challenging endeavor. This is particularly true in the field of neuroscience, where multiple, tightly regulated periods of new protein synthesis in different cell-types are thought to facilitate intricate neurological functions, such as memory formation. Current methods for labeling the

Indexed as

Protein BiosynthesisProteomeAnimalsBrainHumansLightMethionine-tRNA LigaseMiceMice, Inbred C57BLNeuronsNorleucineProteomicsUltraviolet RaysMethionine-tRNA LigaseNorleucineProteomecell-type specificde novo proteomelight-induciblemRNA translationphotocagephotopharmacology

Identifiers

PMID39307974
PMCPMC11450754

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.