ArticleFrontiers in microbiology2024
Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization.
Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Correlation of glycemic variability with the risk of atrial fibrillation and in-hospital mortality in patients diagnosed with obstructive sleep apnea: a retrospective study based on the Medical Information Mart for Intensive Care database.Journal of thoracic disease · 2026Article
- Disrupted glutamate-gaba balance in children with adenoid hypertrophy:a targeted metabolomic and clinical correlation study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Causal Association Between Gut Microbiota and Sleep Apnoea Identified by Bayesian Weighted Mendelian Randomisation.Journal of cellular and molecular medicine · 2026Article
- Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings.Nutrition journal · 2025Review
- Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study.Scientific reports · 2025Article
- The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2025Article
- White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis.Nature and science of sleep · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have identified a clinical association between gut microbiota and Obstructive sleep apnea (OSA), but the potential causal relationship between the two has not been determined. Therefore, we aim to utilize Mendelian randomization (MR) to investigate the potential causal effects of gut microbiota on OSA and the impact of OSA on altering the composition of gut microbiota. Methods: Bi-directional MR and replicated validation were utilized. Summary-level genetic data of gut microbiota were derived from the MiBioGen consortium and the Dutch Microbiome Project (DMP). Summary statistics of OSA were drawn from FinnGen Consortium and Million Veteran Program (MVP). Inverse-variance-weighted (IVW), weighted median, MR-Egger, Simple Mode, and Weighted Mode methods were used to evaluate the potential causal link between gut microbiota and OSA. Results: We identified potential causal associations between 23 gut microbiota and OSA. Among them, Conclusion: Our study implicates the potential bi-directional causal effects of the gut microbiota on OSA, potentially providing new insights into the prevention and treatment of OSA through specific gut microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.