ReviewCureus2024
A Comprehensive Review of Metabolic Syndrome and Its Role in Cardiovascular Disease and Type 2 Diabetes Mellitus: Mechanisms, Risk Factors, and Management.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of overt hypothyroidism and subclinical hypothyroidism in metabolic syndrome: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a meta-analysis on a global scale.Journal of health, population, and nutrition · 2025Pooled it
- Impact of Dietetic Counseling Combined With Digital Tools on Obesity-Related Indices in Greek Adults: The GATEKEEPER Study.Obesity (Silver Spring, Md.) · 2026Trial
- Observational
- Nutritional Modulation in Aging and Metabolic Syndrome: Combating Obesity, Vascular Disease, and Frailty.Nutrients · 2026Article
- Vitamin D and Metabolic Syndrome: Molecular Mechanisms and Clinical Implications: A Narrative Review.International journal of molecular sciences · 2026Review
- Article
- The Gut-Brain Axis in Metabolic Syndrome: Emerging Mechanisms and Perspectives in Personalized Medicine.International journal of molecular sciences · 2026Review
- Combustible Cigarette Smoking, Electronic Cigarette Use, and Metabolic Syndrome in a Working Population.Epidemiologia (Basel, Switzerland) · 2026Article
- The Inflammaging-Redox-InflammamiR Axis in Metabolic Aging: From Diagnostic Clusters to Integrated Risk Phenotypes.Biomolecules · 2026Review
- Sex-specific associations between grip strength and metabolic syndrome in Korean adults: a nationally representative cross-sectional study.Preventive medicine reports · 2026Article
- Sebacic Acid: A Multifunctional Medium-Chain Dicarboxylic Acid in Metabolic Regulation and Tissue Regeneration.Current issues in molecular biology · 2026Review
- Impact of MetS on Long-Term Prognosis Among STEMI Patients Treated with pPCI-Ten-Year Follow-Up Study.Medical sciences (Basel, Switzerland) · 2026Article
- Inverse associations between the dietary diabetes risk reduction score and dietary phytochemical index with metabolic syndrome and its components: a cross-sectional analysis of the Fasa adult cohort study in rural Iran.BMC endocrine disorders · 2026Article
- Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats.Journal of molecular neuroscience : MN · 2026Article
- Observational
- Mechanisms and clinical implications of oxidative stress-mediated endometrial receptivity impairment in polycystic ovary syndrome.Journal of ovarian research · 2026Review
- Global Trends in Bariatric Surgery for the Treatment of Metabolic Syndrome: A Bibliometric and Visualization Analysis.Obesity surgery · 2026Article
- Multi-trajectory modeling of metabolic syndrome indicators and cardiovascular disease risk: a study based on health examination big data.BMC endocrine disorders · 2026Article
- Current Concepts in Probiotic Safety and Efficacy.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome is a multifaceted metabolic disorder characterized by a constellation of interconnected risk factors, including insulin resistance, abdominal obesity, dyslipidemia, and hypertension. These components collectively predispose individuals to an elevated risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The prevalence of metabolic syndrome has escalated globally, paralleling the rise in obesity rates and sedentary lifestyles. This review explores the pathophysiology underlying metabolic syndrome, emphasizing its role in the development and progression of CVD and T2DM. Epidemiological data underscore the substantial public health burden metabolic syndrome poses, necessitating effective preventive strategies and management approaches. The current diagnostic criteria and screening tools are discussed, highlighting their utility in clinical practice. Management strategies encompass lifestyle modifications, pharmacotherapy, and surgical interventions, each targeting specific components of metabolic syndrome to mitigate cardiovascular and metabolic risks. The challenges in diagnosing and managing metabolic syndrome are addressed alongside emerging research directions to enhance prevention and treatment outcomes. By elucidating the intricate relationship between metabolic syndrome, CVD, and T2DM, this review aims to guide healthcare practitioners in optimizing patient care and advancing public health initiatives to combat this pervasive syndrome.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.