Evidence map›Paper›PMID 39312031›Full record

ArticleJournal of assisted reproduction and genetics2024

CATSPER2 and SPEF2 are potential molecular markers for boar sperm quality: a population association study.

Zulfiqar Ahmed, Min Liu, Shuntao Huang, Dequan Xu

Abstract read
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Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zulfiqar AhmedKey Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, and Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubie, People's Republic of China.
Min LiuKey Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, and Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubie, People's Republic of China.
Shuntao HuangKey Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, and Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubie, People's Republic of China.
Dequan XuKey Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, and Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubie, People's Republic of China. dequanxu@126.com.ORCID http://orcid.org/0009-0009-8022-5640

Funding

Hubei Provincial Key Laboratory of Metallurgical Industry Process System Science 2019-620-000-001-30National Key Research and Development Program of China 2021YFD1301201Science and Technology Project of Xinjiang Production and Construction Corps S2021AB3424
6 · The paper itself

Abstract

purposeThis study investigates the role of cation channel sperm associated 2 (CATSPER2) and sperm flagella 2 (SPEF2) genes in boar spermatogenesis, focusing on their association with sperm quality traits in boars.

methodsUtilizing targeted next-generation sequencing, we identified and genotyped two polymorphisms in CATSPER2 (rs341636020G > A, rs326912346G > T) and three variants in SPEF2 (rs320839956A > G, rs334209514C > A, rs325319860C > T) across three boar breeds (Duroc, n = 181; Landrace, n = 87; Large White, n = 52).

resultsOur results confirmed the presence of the specified single nucleotide polymorphisms (SNPs), adhering to association study criteria. In CATSPER2, significant associations were detected between rs341636020G > A and sperm curvilinear velocity (VCL) in Duroc and Landrace boars, and between rs326912346G > T and straight velocity (VSL) in Duroc and Large White boars. For SPEF2, rs320839956A > G was significantly linked to sperm viability in Duroc and Landrace and to sperm concentration (SCON) in Large White boars. Additionally, rs334209514C > A and rs325319860C > T showed significant associations with SCON and VCL respectively, in Doruc and Landrace boars.

conclusionsOverall, our findings suggest that CATSPER2 and SPEF2 SNPs significantly impact boar sperm quality traits. These genetic markers have the potential to enhance boar fertility through selective breeding programs, contributing to the optimization of reproductive performance in pigs.

Indexed as

Polymorphism, Single NucleotideSpermatozoaSperm MotilityAnimalsBreedingCalcium ChannelsGenetic Association StudiesGenotypeMaleSemen AnalysisSpermatogenesisSperm CountSwineCalcium ChannelsAssociationMolecular markersPolymorphismSpermatogenesisTraits

Identifiers

PMID39312031
PMCPMC11621296

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.