Evidence map›Paper›PMID 39312853›Full record

ArticleJournal of psychiatric research2024

Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration.

Maximilian Kiebs, Danielle C Farrar, Antoine Yrondi, Narcis Cardoner, Noora Tuovinen, Ronny Redlich, Udo Dannlowski, Carles Soriano-Mas, Annemiek Dols, Akihiro Takamiya and 37 more

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In one paragraph

Article in Journal of psychiatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Maximilian KiebsDepartment of Psychiatry and Psychotherapy, School of Medicine and Health Sciences, University of Oldenburg, Oldenberg, Germany; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany. Electronic address: m.kiebs@uol.de.
Danielle C FarrarDepartment of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Antoine YrondiService de Psychiatrie et de Psychologie Médicale, Centre Expert Dépression Résistante FondaMental, CHU de Toulouse, Hôpital Purpan, ToNIC Toulouse NeuroImaging Centre, Toulouse, France; Université de Toulouse, INSERM, UPS, Toulouse, France.
Narcis CardonerSant Pau Mental Health Research Group, Institut d'Investigació Biomèdica Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Psychiatry and Forensic Medicine, School of Medicine Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain; Network Center for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Noora TuovinenDepartment of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, Division of Psychiatry I, Medical University of Innsbruck, Innsbruck, Austria.
Ronny RedlichDepartment of Psychology, University of Halle, Germany; Institute of Translational Psychiatry, University of Muenster, Germany; Halle-Jena-Magdeburg, German Center for Mental Health (DZPG), Germany.
Udo DannlowskiInstitute of Translational Psychiatry, University of Muenster, Germany.
Carles Soriano-MasNetwork Center for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Psychiatry and Mental Health Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Social Psychology and Quantitative Psychology, Institute of Neurosciences, Universitat de Barcelona - UB, Barcelona, Spain.
Annemiek DolsDepartment of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Psychiatry, Amsterdam UMC location, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Akihiro TakamiyaDepartment of Neurosciences, Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium; Hills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, Tokyo, Japan.
Indira TendolkarDepartment of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
Katherine L NarrDepartments of Neurology and Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Randall EspinozaDepartments of Neurology and Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Maarten LaroyDepartment of Neurosciences, Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Philip van EijndhovenDepartment of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
Esmée VerwijkDepartment of Psychology, Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands; Department of Medical Psychology, UMC Amsterdam, Amsterdam, the Netherlands; ECT-Department, Parnassia Psychiatric Institute, The Hague, the Netherlands.
Jeroen van WaardeDepartment of Psychiatry, Rijnstate, Arnhem, the Netherlands.
Joey VerdijkDepartment of Psychiatry, Rijnstate, Arnhem, the Netherlands.
Hannah B MaierDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany.
Pia NordanskogCenter for Social and Affective Neuroscience (CSAN), Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Psychiatry in Linköping, Linköping, Sweden.
Guido van WingenDepartment of Psychiatry, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Neuroscience Amsterdam, the Netherlands.
Linda van DiermenDepartment of Psychiatry, University Hospital of Liège, Liege, Belgium; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.
Louise EmsellDepartment of Neurosciences, Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium; Geriatric Psychiatry, University Psychiatry Center (UPC), KU Leuven, Leuven, Belgium.
Filip BouckaertDepartment of Neurosciences, Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium; Geriatric Psychiatry, University Psychiatry Center (UPC), KU Leuven, Leuven, Belgium.
Jonathan ReppleDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Joan A CamprodonDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin S C WadeDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
K Tristan DonaldsonDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Leif OltedalDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Ute KesslerDepartment of Psychiatry, Haukeland University Hospital, Bergen, Norway; University of Bergen, Bergen, Norway.
Åsa HammarDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Department of Clinical Sciences Lund, Psychiatry, Faculty of Medicine, Lund University, Lund, Sweden; Office for Psychiatry and Habilitation, Psychiatry Research Skåne, Skåne, Sweden.
Pascal SienaertAcademic Center for ECT and Neuromodulation (AcCENT), Department of Neurosciences, Neuropsychiatry, University Psychiatry Center (UPC), KU Leuven, Leuven, Belgium.
Kaat HebbrechtAcademic Center for ECT and Neuromodulation (AcCENT), Department of Neurosciences, Neuropsychiatry, University Psychiatry Center (UPC), KU Leuven, Leuven, Belgium.
Mikel UrretavizcayaNetwork Center for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Neurosciences Group - Psychiatry and Mental Health, Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, Barcelona, Spain.
Jean-Baptiste BelgeDepartment of Psychiatry, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Miklos ArgyelanInstitute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA; Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
Mate BaraditsDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
Jasmien ObbelsAcademic Center for ECT and Neuromodulation (AcCENT), Department of Neurosciences, Neuropsychiatry, University Psychiatry Center (UPC), KU Leuven, Leuven, Belgium.
Bogdan DraganskiDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Neurology Department, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Alexandra PhilipsenDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Alexander SartoriusDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Didericke RhebergenDepartment of Psychiatry, Amsterdam UMC location, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; GGZ Central, Mental Health Institute, Amersfoort, the Netherlands.
Olga Therese OusdalDepartment of Biomedicine, Faculty of Medicine, University of Bergen, Norway.
René HurlemannDepartment of Psychiatry and Psychotherapy, School of Medicine and Health Sciences, University of Oldenburg, Oldenberg, Germany.
Shawn McClintockDivision of Psychology, Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
Christopher C AbbottDepartment of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA. Electronic address: CAbbott@salud.unm.edu.

Funding

1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128690 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Katherine L Narr · 2022 to 2026
$2.9M
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128692 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher C Abbott · 2022 to 2026
$2.6M
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128691 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn M McClintock · 2022 to 2026
$2.6M
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depressionR33MH125126 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2023 to 2025
$2.0M
Electrical Field and Neuroimaging Based Prediction of ECT Induced Clinical and Cognitive EffectsR21MH119616 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ARGYELAN, MIKLOS · 2019 to 2020
$454k
NIMH NIH HHS R01 MH128690NIMH NIH HHS R01 MH128691NIMH NIH HHS R01 MH128692NIMH NIH HHS R21 MH119616NIMH NIH HHS R33 MH125126
6 · The paper itself

Abstract

The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data. Here, we summarize the existing GEMRIC cognitive data and provide recommendations for prospective data collection for future ECT-imaging investigations. We describe the criteria for selection of cognitive measures for mega-analyses: Trail Making Test Parts A (TMT-A) and B (TMT-B), verbal fluency category (VFC), verbal fluency letter (VFL), and percent retention from verbal learning and memory tests. We performed longitudinal data analysis focused on the pre-/post-ECT assessments with healthy comparison (HC) subjects at similar timepoints and assessed associations between demographic and ECT parameters with cognitive changes. The study found an interaction between electrode placement and treatment number for VFC (F(1,107) = 4.14, p = 0.04). Higher treatment was associated with decreased VFC performance with right unilateral electrode placement. Percent retention showed a main effect for group, with post-hoc analysis indicating decreased cognitive performance among the HC group. However, there were no significant effects of group or group interactions observed for TMT-A, TMT-B, or VFL. We assessed the current GEMRIC cognitive data and acknowledge the limitations associated with this data set including the limited number of neuropsychological domains assessed. Aside from the VFC and treatment number relationship, we did not observe ECT-mediated neurocognitive effects in this investigation. We provide prospective cognitive recommendations for future ECT-imaging investigations focused on strong psychometrics and minimal burden to subjects.

Indexed as

Electroconvulsive TherapyMagnetic Resonance ImagingAdultAgedBrainFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsCognitionDepressionElectroconvulsive therapyNeuropsychology

Identifiers

PMID39312853
PMCPMC11869118

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.