ArticleNature metabolism2024
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
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- Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.Annals of the New York Academy of Sciences · 2026Review
- Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways.Experimental & molecular medicine · 2026Article
- MicroRNA-Driven Regulation of β-Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives.Acta physiologica (Oxford, England) · 2026Review
- Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effects.Diabetologia · 2026Article
- Heterogeneous endocrine cell composition defines human islet functional phenotypes.Nature communications · 2026Article
- β-Cell Obligation in α-Cell Glucagon Response to Low Glucose.Research square · 2026Article
- Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells.Cell reports · 2026Article
- Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats.Endocrinology · 2026Article
- Metabolic mediators linking type 1 diabetes mellitus to osteoporosis.Archives of medical science : AMS · 2026Article
- Enhanced crosstalk between α- and δ-cells promotes recurrent hypoglycaemia.Nature metabolism · 2026Article
- Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.Nature metabolism · 2026Article
- The crucial role of potassium ion channels in diabetes mellitus and its complications: A review.Channels (Austin, Tex.) · 2025Review
- Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps.International journal of molecular sciences · 2025Review
- Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low-density Cx36 gap junctions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Heterogeneous endocrine cell composition defines human islet functional phenotypes.bioRxiv : the preprint server for biology · 2025Article
- Proinflammatory cytokine-induced alpha cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism.Diabetologia · 2025Article
- Islet delta-cell architecture is remodelled in the human pancreas during type 1 diabetes.Scientific reports · 2025Article
- Lessons from a model: early glucagon dysfunction in type 2 diabetes.Pflugers Archiv : European journal of physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Thomas G Hill *Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Rui Gao *Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0845-1370
Anna BenrickMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.
Lakshmi KothegalaMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.
Nils RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Cristiano SantosMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.ORCID http://orcid.org/0000-0002-9972-5583
Samuel AcremanOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5117-4447
Linford J BriantOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Haiqiang DouMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.ORCID http://orcid.org/0000-0002-1551-4114
Nikhil R GandasiMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.
Claudia GuidaOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Elizabeth HaythorneDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3097-9240
Marsha WallaceNuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, UK.
Jakob G KnudsenOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7237-8457
Caroline MirandaOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Johan TolöMetabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.ORCID http://orcid.org/0000-0001-9648-4721
Anne ClarkOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Lucy DavisonNuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, UK.
Joachim StørlingSteno Diabetes Center Copenhagen, Translational Type 1 Diabetes Research, Herlev, Denmark.
Andrei TarasovOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Frances M AshcroftDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6970-1767
Patrik RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. patrik.rorsman@drl.ox.ac.uk.ORCID http://orcid.org/0000-0001-7578-0767
Quan ZhangOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. quan.zhang@ocdem.ox.ac.uk.ORCID http://orcid.org/0000-0002-3626-4855
Funding
Diabetes UK 14/0005128Leona M. and Harry B. Helmsley Charitable Trust (Helmsley Charitable Trust) G-1912-03553Leona M. and Harry B. Helmsley Charitable Trust (Helmsley Charitable Trust) G-2305-06047RCUK | Medical Research Council (MRC) MR/T002107/1RCUK | Medical Research Council (MRC) MR/VO11979/1Vetenskapsrådet (Swedish Research Council) 2013-7107Wellcome TrustWellcome Trust (Wellcome) 201325/Z/16/Z
Abstract
Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion
Indexed as
Diabetes Mellitus, Type 1GlucagonHypoglycemiaInsulin-Secreting CellsAnimalsFemaleGlucoseHumansMaleMiceMice, Inbred NODSomatostatinSomatostatin-Secreting CellsGlucagonGlucoseSomatostatin
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.