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ArticleBiological trace element research2025

What Dietary Vitamins and Minerals Might Be Associated with Paraoxonase-1 Serum Levels in Patients with Coronary Artery Disease?

Masoumeh Rafinezhad, Sorayya Kheirouri, Mohsen Abbasnezhad, Mohammad Alizadeh

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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Masoumeh RafinezhadStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Sorayya KheirouriDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Kheirouris@tbzmed.ac.ir.ORCID http://orcid.org/0000-0001-6249-4462
Mohsen AbbasnezhadCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. abbasnejadm@tbzmed.ac.ir.
Mohammad AlizadehDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraoxonase-1 (PON-1) is an antioxidant enzyme inversely associated with atherosclerosis incidence. Dietary antioxidants help to increase PON-1 serum levels. Since most vitamins and minerals have antioxidant properties, this research aimed to examine the association between PON-1 serum levels and dietary intake of vitamins and minerals in patients with coronary artery disease (CAD). In this cross-sectional study, 102 inpatients with CAD and 60 healthy individuals participated. The average dietary vitamins and minerals intake were computed using information from the food frequency questionnaire with the assistance of Nutritionist IV software. The serum PON-1 level was measured using the ELISA method. Regarding minerals, serum PON-1 level was positively correlated with dietary calcium (β = 0.57, p = 0.001), phosphorus (β = 0.52, p = 0.004), and potassium intake (β = 0.40, p = 0.03), but inversely associated with dietary consumption of iron (β =  - 0.43, p = 0.04), and sodium (β =  - 0.41, p = 0.02). Concerning vitamins, serum levels of PON-1 were positively associated with vitamin B6 (β = 0.53, p = 0.01) and riboflavin (β = 0.44, p = 0.03) but inversely correlated with niacin (β =  - 0.49, p = 0.03). The serum level of PON-1 might be associated with the dietary intake of minerals and vitamins. Therefore, a diet rich in certain minerals and vitamins may be advantageous in increasing serum PON-1 levels and preventing CAD.

Indexed as

AryldialkylphosphataseCoronary Artery DiseaseMineralsVitaminsAgedCross-Sectional StudiesDietFemaleHumansMaleMiddle AgedAryldialkylphosphataseMineralsPON1 protein, humanVitaminsCoronary artery diseaseMineralsParaoxonase-1Vitamins

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.