Evidence map›Paper›PMID 39314009›Full record

ArticleCurrent eye research2025

Temporal Regulation of Myopia and Inflammation-Associated Pathways in the Interphotoreceptor Retinoid-Binding Protein Knockout Mouse Model.

Shanu Markand, Somin Kim, Micah A Chrenek, Salma Ferdous, Priyanka Priyadarshani, Jeffrey H Boatright, John M Nickerson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shanu MarkandOphthalmology Department, Emory University, Atlanta, GA, USA.
Somin KimOphthalmology Department, Emory University, Atlanta, GA, USA.
Micah A ChrenekOphthalmology Department, Emory University, Atlanta, GA, USA.
Salma FerdousOphthalmology Department, Emory University, Atlanta, GA, USA.
Priyanka PriyadarshaniOphthalmology Department, Emory University, Atlanta, GA, USA.
Jeffrey H BoatrightOphthalmology Department, Emory University, Atlanta, GA, USA.
John M NickersonOphthalmology Department, Emory University, Atlanta, GA, USA.

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI GEISERT, ELDON E · 1986 to 2025
$15.3M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
Ocular Growth, Emmetropia, and Interphotoreceptor Retinoid-Binding Protein (IRBP)R01EY021592 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, IUVONE, P MICHAEL · 2013 to 2021
$3.3M
The RPE and Recovery of the Blood Retina BarrierR01EY028450 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, GROSSNIKLAUS, HANS E. · 2018 to 2022
$2.4M
Exercise-induced Retinal NeuroprotectionR01EY028859 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, PARDUE, MACHELLE T. · 2018 to 2021
$2.0M
Deciphering the Usher I protein interactome using a genetic approachR01DC009246 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI ZHENG, QING Y · 2009 to 2013
$1.6M
Retina Differential Gene Expression Modifiers that affect VisionF31EY028855 · NEI · EMORY UNIVERSITY · PI FERDOUS, SALMA · 2018 to 2020
$125k
NEI NIH HHS F31 EY028855NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY021592NEI NIH HHS R01 EY028450NEI NIH HHS R01 EY028859NEI NIH HHS T32 EY007092NIDCD NIH HHS R01 DC009246NIGMS NIH HHS T32 GM008490RRD VA I01 RX002806RRD VA I21 RX001924
6 · The paper itself

Abstract

purposeMyopia is a complex disorder with etiology involving an interplay between several genetic and environmental factors. Interphotoreceptor retinoid-binding protein (IRBP) is found in the subretinal space and is crucial in the visual cycle. The interphotoreceptor retinoid-binding protein knockout mouse (IRBP KO) was established as a model system to understand myopia and retinal degeneration. The current study investigated genes associated with myopia, retinal homeostasis, and inflammation in IRBP KO.

methodsRNA from retinas of congenic IRBP KO and wild-type C57BL/6J (WT) mice at postnatal day 5 (P5), P40, and P213 were subjected to digital droplet PCR (ddPCR) using a Bio-Rad automated droplet generator and QX200 reader. Target genes were selected based on genome-wide association studies, animal models, myopia studies, and other genes associated with retinal homeostasis and inflammation. HPRT, a housekeeping gene, was used for normalization. An average expression ratio (target/HPRT) and standard deviation (SD) were calculated. ANOVA assessed statistical significance, and a

resultsThe ddPCR data analysis indicated that numerous myopia and inflammation-associated genes were differentially regulated in IRBP KO retinas with distinct temporal variation (upregulated at P5, decreased at P40, and no change at P213 relative to WT).

conclusionsData analysis indicated significant contributions from

Indexed as

Eye ProteinsGene Expression RegulationMyopiaRetinaRetinol-Binding ProteinsAnimalsDisease Models, AnimalInflammationMiceMice, Inbred C57BLMice, KnockoutRetinol-Binding Proteins, InterstitialEye ProteinsRetinol-Binding ProteinsRetinol-Binding Proteins, InterstitialC1qagenesIRBPmyopiaretinal degeneration

Identifiers

PMID39314009
PMCPMC11774681

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.