Evidence map›Paper›PMID 39314368›Full record

ArticlebioRxiv : the preprint server for biology2024

Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance.

Nicolas Millet, Jinendiran Sekar, Norma V Solis, Antoine Millet, Felix E Y Aggor, Asia Wildeman, Michail S Lionakis, Sarah L Gaffen, Nicholas Jendzjowsky, Scott G Filler and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nicolas MilletDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Jinendiran SekarDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Norma V SolisDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Antoine MilletThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Felix E Y AggorUniversity of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, USA.
Asia WildemanDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Sarah L GaffenUniversity of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, USA.
Nicholas JendzjowskyThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Scott G FillerDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.
Marc SwidergallDivision of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5261-6267

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
Oral commensal fungi and structural immunityR01DE031382 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Marc Swidergall · 2022 to 2026
$2.5M
Regulation of Candida albicans Pathogenesis by Protein Kinase and Transcription Factor NetworksR01AI177254 · NIAID · UNIVERSITY OF IOWA · PI Scott G Filler, Damian J Krysan · 2024 to 2026
$2.3M
Unraveling transcriptomic and functional changes to immune sensing neuronal ganglia in response to allergy and bacteriaR21AI159221 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI JENDZJOWSKY, NICHOLAS · 2022 to 2023
$438k
Asthmatic inflammation requires neuronal upregulation of B-cellsR56AI175328 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI JENDZJOWSKY, NICHOLAS · 2024 to 2024
$332k
NIAID NIH HHS R01 AI177254NIAID NIH HHS R21 AI159221NIAID NIH HHS R56 AI175328NIDCR NIH HHS R01 DE031382NIDCR NIH HHS R37 DE022550
6 · The paper itself

Abstract

Mucosal barrier integrity is vital for homeostasis with commensal organisms while preventing pathogen invasion. We unexpectedly found that fungal-induced immunosurveillance enhances resistance to fungal outgrowth and tissue invasion by remodeling the oral mucosal epithelial barrier in mouse models of adult and neonatal

Indexed as

Candida albicansgp130IL-10RBIL-22RA1JAKoral epitheliumSTAT3Th17Th22TYK2

Identifiers

PMID39314368
PMCPMC11419061

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.