Evidence map›Paper›PMID 39314378›Full record

ArticlebioRxiv : the preprint server for biology2025

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration.

Yu Deng, Tatsat Banerjee, Satomi Matsuoka, Debojyoti Biswas, Liz A Kurtz, Jane Borleis, Yu Long, Parijat Banerjee, Huiwang Zhan, Dhiman Sankar Pal and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu DengDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0673-1352
Tatsat BanerjeeDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-3490-3959
Satomi MatsuokaLaboratory of Single Molecule Biology, Graduate School of Science and Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Debojyoti BiswasLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.
Liz A KurtzDepartment of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, USA.ORCID 0009-0008-2562-1870
Jane BorleisDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Yu LongDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Parijat BanerjeeDepartment of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, USA.
Huiwang ZhanDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Dhiman Sankar PalDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8442-3507
Nathan H RoyDepartment of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Masahiro UedaLaboratory of Single Molecule Biology, Graduate School of Science and Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Pablo A IglesiasDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0840-155X
Peter N DevreotesDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Funding

Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
ZEISS AXIOVERT 200-M FOR TIME-LAPSE MICROSCOPY: KIDNEYS10RR021200 · NCRR · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 2005 to 2005
$174k
NIGMS NIH HHS R35 GM118177NIH HHS S10 OD016374
6 · The paper itself

Abstract

Symmetry breaking is a fundamental process that underlies key cellular behaviors such as cell polarity and migration, but the mechanism - how a uniform plasma membrane spontaneously transitions to an asymmetric state - is still unknown. Here in this study, using a combination of

Identifiers

PMID39314378
PMCPMC11419139

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.